ReviewInternational orthopaedics2014
Using genes to facilitate the endogenous repair and regeneration of orthopaedic tissues.
Review in International orthopaedics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Gene Therapy for Regenerative Medicine.Pharmaceutics · 2023Review
- New frontiers of tendon augmentation technology in tissue engineering and regenerative medicine: a concise literature review.The Journal of international medical research · 2022Review
- Current and future trends in periodontal tissue engineering and bone regeneration.Plastic and aesthetic research · 2021Article
- Mohawk is a transcription factor that promotes meniscus cell phenotype and tissue repair and reduces osteoarthritis severity.Science translational medicine · 2020Article
- Bioengineering Approaches to Accelerate Clinical Translation of Stem Cell Therapies Treating Osteochondral Diseases.Stem cells international · 2020Review
- Genetic modification of scAAV-equine-BMP-2 transduced bone-marrow-derived mesenchymal stem cells before and after cryopreservation: An "off-the-shelf" option for fracture repair.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Article
- The challenges of promoting osteogenesis in segmental bone defects and osteoporosis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Review
- Dual non-viral gene delivery from microparticles within 3D high-density stem cell constructs for enhanced bone tissue engineering.Biomaterials · 2018Article
- Tendinopathy: injury, repair, and current exploration.Drug design, development and therapy · 2018Review
- Changing Paradigms in Cranio-Facial Regeneration: Current and New Strategies for the Activation of Endogenous Stem Cells.Frontiers in physiology · 2016Review
- The role of growth factors in stem cell-directed chondrogenesis: a real hope for damaged cartilage regeneration.International orthopaedics · 2015Review
- Gene therapy approaches to regenerating the musculoskeletal system.Nature reviews. Rheumatology · 2015Review
- Biologics for tendon repair.Advanced drug delivery reviews · 2015Review
- Native, living tissues as cell seeded scaffolds.Annals of biomedical engineering · 2015Review
- Tissue engineering and regenerative orthopaedics (TERO).International orthopaedics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Traditional tissue engineering approaches to the restoration of orthopaedic tissues promise to be expensive and not well suited to treating large numbers of patients. Advances in gene transfer technology offer the prospect of developing expedited techniques in which all manipulations can be performed percutaneously or in a single operation. This rests on the ability of gene delivery to provoke the sustained synthesis of relevant gene products in situ without further intervention. Regulated gene expression is also possible, but its urgency is reduced by our ignorance of exactly what levels and periods of expression are needed for specific gene products. This review describes various strategies by which gene therapy can be used to expedite the repair and regeneration of orthopaedic tissues. Strategies include the direct injection of vectors into sites of injury, the use of genetically modified, allogeneic cell lines and the intra-operative harvest of autologous tissues that are quickly transduced and returned to the body, either intact or following rapid cell isolation. Data obtained from pre-clinical experiments in animal models have provided much encouragement that such approaches may eventually find clinical application in human and veterinary medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.