ReviewCurrent topics in microbiology and immunology2015
Skin immunization with influenza vaccines.
Review in Current topics in microbiology and immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- The safety, immunogenicity, and acceptability of inactivated influenza vaccine delivered by microneedle patch (TIV-MNP 2015): a randomised, partly blinded, placebo-controlled, phase 1 trial.Lancet (London, England) · 2017Trial
- Gonococcal microparticle vaccine in dissolving microneedles induced immunity and enhanced bacterial clearance in infected mice.International journal of pharmaceutics · 2023Article
- γδ T cells as immunotherapy for malaria: balancing challenges and opportunities.Frontiers in immunology · 2023Article
- Immunologic mechanisms of seasonal influenza vaccination administered by microneedle patch from a randomized phase I trial.NPJ vaccines · 2021Article
- Fabrication of microneedle patches with lyophilized influenza vaccine suspended in organic solvent.Drug delivery and translational research · 2021Article
- Opportunities for biomaterials to address the challenges of COVID-19.Journal of biomedical materials research. Part A · 2020Review
- cGAMP/Saponin Adjuvant Combination Improves Protective Response to Influenza Vaccination by Microneedle Patch in an Aged Mouse Model.Frontiers in immunology · 2020Article
- Stable incorporation of GM-CSF into dissolvable microneedle patch improves skin vaccination against influenza.Journal of controlled release : official journal of the Controlled Release Society · 2018Article
- Intradermal delivery of a fractional dose of influenza H7N9 split vaccine elicits protective immunity in mice and rats.Human vaccines & immunotherapeutics · 2018Article
- Skin immunization by microneedle patch overcomes statin-induced suppression of immune responses to influenza vaccine.Scientific reports · 2017Article
- Microneedle patch for immunization of immunocompromised hosts.Oncotarget · 2017Article
- Microneedle patch delivery of influenza vaccine during pregnancy enhances maternal immune responses promoting survival and long-lasting passive immunity to offspring.Scientific reports · 2017Article
- Microneedles: quick and easy delivery methods of vaccines.Clinical and experimental vaccine research · 2017Article
- Challenges and Future Prospects for the Delivery of Biologics: Oral Mucosal, Pulmonary, and Transdermal Routes.The AAPS journal · 2017Article
- Long-term stability of influenza vaccine in a dissolving microneedle patch.Drug delivery and translational research · 2017Article
- Improved immunogenicity of individual influenza vaccine components delivered with a novel dissolving microneedle patch stable at room temperature.Drug delivery and translational research · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Problems with existing influenza vaccines include the strain specificity of the immune response, resulting in the need for frequent reformulation in response to viral antigenic drift. Even in years when the same influenza strains are prevalent, the duration of immunity is limited, and results in the need for annual revaccination. The immunogenicity of the present split or subunit vaccines is also lower than that observed with whole inactivated virus, and the vaccines are not very effective in high risk groups such as the young or the elderly. Vaccine coverage is incomplete, due in part to concerns about the use of hypodermic needles for delivery. Alternative approaches for vaccination are being developed which address many of these concerns. Here we review new approaches which focus on skin immunization, including the development of needle-free delivery systems which use stable dry formulations and induce stronger and longer-lasting immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.