Trial reportEuropean radiology2015
DTI for the assessment of disease stage in patients with glomerulonephritis--correlation with renal histology.
Trial report in European radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Diffusion-weighted imaging for staging chronic kidney disease: a meta-analysis.The British journal of radiology · 2018Pooled it
- Diffusion Tensor Imaging of the Kidney: Design and Evaluation of a Reliable Processing Pipeline.Scientific reports · 2019Trial
- FMultifunctional magnetic resonance imaging for the assessment of renal pathological alterations in IgA nephropathy.BMC nephrology · 2026Article
- Assessing kidney fibrosis via multiparametric MRI in native kidney and allografts.Clinical kidney journal · 2026Article
- Preoperative assessment of split renal function in patients with renal cell carcinoma by APTw driven multiparameter MRI.BMC medical imaging · 2026Article
- Non-invasive assessment techniques for renal fibrosis: advances and perspectives.Renal failure · 2025Review
- Prospective evaluation of arterial spin labeling and diffusion tensor imaging-magnetic resonance imaging for the non-invasive assessment of renal allograft dysfunction.Quantitative imaging in medicine and surgery · 2025Article
- Multiparametric MRI: can we assess renal function differently?Clinical kidney journal · 2025Review
- Diffusion tractography of kidney by high angular resolution diffusion imaging.Magnetic resonance letters · 2024Article
- Renal MRI: From Nephron to NMR Signal.Journal of magnetic resonance imaging : JMRI · 2023Review
- Advances in imaging techniques to assess kidney fibrosis.Renal failure · 2023Review
- Longitudinal multiparametric MRI of traumatic spinal cord injury in animal models.Magnetic resonance imaging · 2023Review
- Renal functional and interstitial fibrotic assessment with non-Gaussian diffusion kurtosis imaging.Insights into imaging · 2022Article
- Study of renal parenchymal changes by diffusion tensor imaging in diabetic nephropathy.Polish journal of radiology · 2022Article
- Alterations of Renal Function in Patients with Diabetic Kidney Disease: A BOLD and DTI Study.Computational intelligence and neuroscience · 2022Article
- Diffusion tensor imaging of renal cortex in lupus nephritis.Japanese journal of radiology · 2021Article
- Diffusion tensor imaging for the study of early renal dysfunction in patients affected by bardet-biedl syndrome.Scientific reports · 2021Article
- Diffusion tensor imaging based multiparametric characterization of renal lesions in infants with urinary tract infections: an explorative study.BMC pediatrics · 2021Article
- Renal tubular dilation and fibrosis after unilateral ureter obstruction revealed by relaxometry and spin-lock exchange MRI.NMR in biomedicine · 2021Article
- Diffusion Tensor Imaging in Rat Models of Preclinical Diabetic Nephropathy: A Preliminary Study.Frontiers in endocrinology · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate whether DTI allows assessment of renal impairment and pathology in patients with chronic glomerulonephritis. MATERIALS AND
methodsSeventy-five patients and 20 healthy volunteers were enrolled in this study. Renal function and kidney biopsies were evaluated. For DTI, a respiratory-triggered coronal EPI sequence was performed (TR, 1400 ms; TE, 76 ms; diffusion direction, 6; NEX, 4; b values, 0 and 600 s/mm2; slices thickness, 6 mm, with no intersection gap). Renal ADC and FA values were calculated and compared between the groups. Correlations between ADC/FA and histopathology were evaluated.
resultsADC values decreased with increased stages. ADC differences in renal parenchyma at different disease stages were found, with the exception of the control group compared with stage 1 patients; similar results were obtained for FA. ADC values in the cortex and medulla in stage 1-3 patients were both statistically different, similar to the FA values. A significant negative correlation was found between the percentage of glomerulosclerosis and FA in the renal cortex (r = -0.74), similar to the degree of tubulointerstitial fibrosis with FA in the medulla (r = -0.76).
conclusionsADC and FA values are correlated with the degree of renal impairment, the percentage of glomerulosclerosis, and area of interstitial fibrosis. KEY POINTS: • DTI can be used to assess renal function impairment in patients with chronic glomerulonephritis. • ADC and FA values were correlated with tubulointerstitial fibrosis and glomerulosclerosis. • Identification of renal impairment is helpful for timely treatment. • DTI can be used for non-invasive assessment of renal pathology.
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