ReviewCellular and molecular life sciences : CMLS2014
Synonymous codons, ribosome speed, and eukaryotic gene expression regulation.
Review in Cellular and molecular life sciences : CMLS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- The Tor pathway, ribosome concentration, and wobble decoding mediate inhibitory effects of the Leu-Pro CUC-CCG codon pair inRNA (New York, N.Y.) · 2026Article
- A transfer RNA inosine modification drives genome-wide synonymous recoding across human commensal bacterial families.PNAS nexus · 2026Article
- Less is more: slow-codon windows enhance eGFP mRNA resilience against RNA interference.Journal of the Royal Society, Interface · 2025Article
- Translation ofFrontiers in molecular biosciences · 2023Review
- Evaluating data integrity in ribosome footprinting datasets through modelled polysome profiles.Nucleic acids research · 2022Article
- Intelligent host engineering for metabolic flux optimisation in biotechnology.The Biochemical journal · 2021Review
- Synonymous mutations that regulate translation speed might play a non-negligible role in liver cancer development.BMC cancer · 2021Article
- A comprehensive analysis of the phylogenetic signal in ramp sequences in 211 vertebrates.Scientific reports · 2021Article
- Structural and functional insights into Archaeoglobus fulgidus m2G10 tRNA methyltransferase Trm11 and its Trm112 activator.Nucleic acids research · 2020Article
- Systematic analysis reveals cis and trans determinants affecting C-to-U RNA editing in Arabidopsis thaliana.BMC genetics · 2020Article
- Developmental regulation of canonical and small ORF translation from mRNAs.Genome biology · 2020Article
- Control of translation elongation in health and disease.Disease models & mechanisms · 2020Review
- Hidden patterns of codon usage bias across kingdoms.Journal of the Royal Society, Interface · 2020Article
- Homeostasis in the Central Dogma of molecular biology: the importance of mRNA instability.RNA biology · 2019Article
- Article
- Ribosome reinitiation can explain length-dependent translation of messenger RNA.PLoS computational biology · 2017Article
- Accurate Recovery of Ribosome Positions Reveals Slow Translation of Wobble-Pairing Codons in Yeast.Journal of computational biology : a journal of computational molecular cell biology · 2017Article
- Identification of the mRNA targets of tRNA-specific regulation using genome-wide simulation of translation.Nucleic acids research · 2016Article
- Discrepancy among the synonymous codons with respect to their selection as optimal codon in bacteria.DNA research : an international journal for rapid publication of reports on genes and genomes · 2016Article
- Optimization of Codon Translation Rates via tRNA Modifications Maintains Proteome Integrity.Cell · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Quantitative control of gene expression occurs at multiple levels, including the level of translation. Within the overall process of translation, most identified regulatory processes impinge on the initiation phase. However, recent studies have revealed that the elongation phase can also regulate translation if elongation and initiation occur with specific, not mutually compatible rate parameters. Translation elongation then limits the overall amount of protein that can be made from an mRNA. Several recently discovered control mechanisms of biological pathways are based on such elongation control. Here, we review the molecular mechanisms that determine ribosome speed in eukaryotic organisms, and discuss under which conditions ribosome speed can become the controlling parameter of gene expression levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.