ArticleJournal of theoretical biology2014
Quantifying the effects of the division of labor in metabolic pathways.
Article in Journal of theoretical biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Guided by the principles of microbiome engineering: Accomplishments and perspectives for environmental use.mLife · 2022Review
- Resource-aware whole-cell model of division of labour in a microbial consortium for complex-substrate degradation.Microbial cell factories · 2022Article
- Article
- Designing microbial communities to maximize the thermodynamic driving force for the production of chemicals.PLoS computational biology · 2021Article
- Global dynamics of the chemostat with overflow metabolism.Journal of mathematical biology · 2021Article
- A piece of the pie: engineering microbiomes by exploiting division of labor in complex polysaccharide consumption.Current opinion in chemical engineering · 2020Article
- The microbial exometabolome: ecological resource and architect of microbial communities.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Enhanced production of heterologous proteins by a synthetic microbial community: Conditions and trade-offs.PLoS computational biology · 2020Article
- Comparative Genome Analysis of the Lignocellulose Degrading BacteriaFrontiers in microbiology · 2020Article
- The social network of microorganisms - how auxotrophies shape complex communities.Nature reviews. Microbiology · 2018Review
- Metabolic division of labor in microbial systems.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- From Genes to Ecosystems in Microbiology: Modeling Approaches and the Importance of Individuality.Frontiers in microbiology · 2017Review
- Article
- Pervasive Selection for Cooperative Cross-Feeding in Bacterial Communities.PLoS computational biology · 2016Article
- Synthetic Ecology of Microbes: Mathematical Models and Applications.Journal of molecular biology · 2016Review
- A functional perspective on phenotypic heterogeneity in microorganisms.Nature reviews. Microbiology · 2015Review
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Authors and funding
3 authors.
Funding
Abstract
Division of labor is commonly observed in nature. There are several theories that suggest diversification in a microbial community may enhance stability and robustness, decrease concentration of inhibitory intermediates, and increase efficiency. Theoretical studies to date have focused on proving when the stable co-existence of multiple strains occurs, but have not investigated the productivity or biomass production of these systems when compared to a single 'super microbe' which has the same metabolic capacity. In this work we prove that if there is no change in the growth kinetics or yield of the metabolic pathways when the metabolism is specialized into two separate microbes, the biomass (and productivity) of a binary consortia system is always less than that of the equivalent monoculture. Using a specific example of Escherichia coli growing on a glucose substrate, we find that increasing the growth rates or substrate affinities of the pathways is not sufficient to explain the experimentally observed productivity increase in a community. An increase in pathway efficiency (yield) in specialized organisms provides the best explanation of the observed increase in productivity.
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