Evidence map›Paper›PMID 25037524›Full record

ArticleSchizophrenia research2014

Impaired functional connectivity of brain reward circuitry in patients with schizophrenia and cannabis use disorder: Effects of cannabis and THC.

Adina S Fischer, Susan Whitfield-Gabrieli, Robert M Roth, Mary F Brunette, Alan I Green

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 4 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 63 citations in OpenAlex.

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  11. Impairment of Synaptic Plasticity by Cannabis, ΔCold Spring Harbor perspectives in medicine · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Adina S FischerDepartment of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Susan Whitfield-GabrieliDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Robert M RothDepartment of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Mary F BrunetteDepartment of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Alan I GreenDepartment of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, NH, USA; Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Electronic address: Alan.I.Green@dartmouth.edu.
Dartmouth College · USInstitute of Cognitive and Brain Sciences · US

Funding

Cannabis, Schizophrenia and Reward: Self-Medication and Agonist Treatment?R01DA034699 · NIDA · DARTMOUTH-HITCHCOCK CLINIC · PI BRUNETTE, MARY FRANCES · 2013 to 2019
$4.3M
Cannabis and Schizophrenia: Self-Medication and Agonist Treatment?R01DA026799 · NIDA · DARTMOUTH COLLEGE · PI GREEN, ALAN I · 2009 to 2010
$1.1M
NIDA NIH HHS DA026799-01NIDA NIH HHS R01 DA026799NIDA NIH HHS R01 DA034699
6 · The paper itself

Abstract

Cannabis use disorder (CUD) occurs in up to 42% of patients with schizophrenia and substantially worsens disease progression. The basis of CUD in schizophrenia is unclear and available treatments are rarely successful at limiting cannabis use. We have proposed that a dysregulated brain reward circuit (BRC) may underpin cannabis use in these patients. In the present pilot study, we used whole-brain seed-to-voxel resting state functional connectivity (rs-fc) to examine the BRC of patients with schizophrenia and CUD, and to explore the effects of smoked cannabis and orally administered delta-9-tetrahydrocannabinol (THC) on the BRC. 12 patients with schizophrenia and CUD and 12 control subjects each completed two fMRI resting scans, with patients administered either a 3.6% THC cannabis cigarette (n=6) or a 15 mg THC capsule (n=6) prior to their second scan. Results revealed significantly reduced connectivity at baseline in patients relative to controls, with most pronounced hypoconnectivity found between the nucleus accumbens and prefrontal cortical BRC regions (i.e., anterior prefrontal cortex, orbitofrontal cortex, and anterior cingulate cortex). Both cannabis and THC administration increased connectivity between these regions, in direct correlation with increases in plasma THC levels. This study is the first to investigate interregional connectivity of the BRC and the effects of cannabis and THC on this circuit in patients with schizophrenia and CUD. The findings from this pilot study support the use of rs-fc as a means of measuring the integrity of the BRC and the effects of pharmacologic agents acting on this circuit in patients with schizophrenia and CUD.

Indexed as

Administration, OralAdultBrainBrain MappingCannabinoid Receptor AgonistsCannabisDronabinolFemaleHumansMagnetic Resonance ImagingMaleMarijuana SmokingNeural PathwaysPilot ProjectsRestRewardCannabinoid Receptor AgonistsDronabinolBrain reward circuitryCannabis use disorderfMRINucleus accumbensResting state functional connectivitySchizophrenia

Identifiers

PMID25037524
PMCPMC4778557
OpenAlexW1985401089

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.