Evidence map›Paper›PMID 25037448›Full record

ReviewBiological research for nursing2015

Shared symptoms and putative biological mechanisms in chronic liver disease: implications for biobehavioral research.

Victoria Menzies, Nancy Jallo, Patricia Kinser, Jo Lynne W Robins, Kyungeh An, Carolyn Driscoll, Angela Starkweather, Jasmohan S Bajaj, Debra E Lyon

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biological research for nursing, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Vitamin C improves gutFuture microbiology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Victoria MenziesVirginia Commonwealth University School of Nursing, Richmond, VA, USA vsmenzies@vcu.edu.
Nancy JalloVirginia Commonwealth University School of Nursing, Richmond, VA, USA.
Patricia KinserVirginia Commonwealth University School of Nursing, Richmond, VA, USA.
Jo Lynne W RobinsVirginia Commonwealth University School of Nursing, Richmond, VA, USA.
Kyungeh AnVirginia Commonwealth University School of Nursing, Richmond, VA, USA.
Carolyn DriscollDepartment of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Angela StarkweatherVirginia Commonwealth University School of Nursing, Richmond, VA, USA.
Jasmohan S BajajDepartment of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Debra E LyonCollege of Nursing, University of Florida, Gainesville, FL.
Virginia Commonwealth University · USUniversity of Florida · US

Funding

Epigenetics and Psychoneurologic Symptoms in Women with Breast CancerR01NR012667 · NINR · VIRGINIA COMMONWEALTH UNIVERSITY · PI JACKSON-COOK, COLLEEN K, LYON, DEBRA E · 2010 to 2014
$3.1M
Center of Excellence in Biobehavioral Approaches to Symptom ManagementP30NR011403 · NINR · VIRGINIA COMMONWEALTH UNIVERSITY · PI GRAP, MARY JO · 2009 to 2013
$2.2M
Spectrum of Neuro-Cognitive Impairment in CirrhosisR01DK087913 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI BAJAJ, JASMOHAN S · 2011 to 2015
$2.0M
Pain Sensitivity in Low Back PainR01NR013932 · NINR · VIRGINIA COMMONWEALTH UNIVERSITY · PI STARKWEATHER, ANGELA RENEE · 2013 to 2015
$1.3M
Hepatic Encephalopathy in Alcoholic Cirrhosis: A Systems Biology ApproachR01AA020203 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI BAJAJ, JASMOHAN S · 2010 to 2012
$1.0M
NIAAA NIH HHS R01 AA020203NIAAA NIH HHS R01AA020203NIDDK NIH HHS R01 DK087913NIDDK NIH HHS R01DK087913NINR NIH HHS P30 NR011403NINR NIH HHS P30NR011403NINR NIH HHS R01 NR012667NINR NIH HHS R01NR012667NINR NIH HHS R01 NR013932NINR NIH HHS R01NR013932
6 · The paper itself

Abstract

Liver disease affects over 25 million people in the United States and, despite advances in medical management resulting in increased survival, a majority of these individuals report multiple co-occurring symptoms that severely impair functioning and quality of life. The purpose of this review is to (1) propose defining these co-occurring symptoms as a symptom cluster of chronic liver disease (CLD), (2) discuss putative underlying biological mechanisms related to CLD, including the liver-gut-brain axis and influence of the microbiome, and (3) discuss the implications for biobehavioral research in this patient population. Biobehavioral research focusing on the interrelated, and possibly synergistic, mechanisms of these symptoms may lead to the development and testing of targeted symptom management interventions for improving function and quality of life in this growing patient population.

Indexed as

Biobehavioral SciencesCentral Nervous SystemHumansImmune SystemLiver DiseasesSyndromebiobehavioralliver diseasemechanismssymptoms

Identifiers

PMID25037448
PMCPMC5818716
OpenAlexW2321094631

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.