ArticlePloS one2014
Genome-wide identification of MAPKK and MAPKKK gene families in tomato and transcriptional profiling analysis during development and stress response.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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73 citing papers in PubMed, 149 citations in OpenAlex.
- Role of cell wall-associated kinases in plant development and defense responses.Molecular biology reports · 2026Review
- Genome-wide identification and functional characterization of MAPKK gene family in Zanthoxylum armatum DC. reveal its potential role in ecological adaptive evolution.BMC genomics · 2026Article
- Transcriptome and Hormone Analysis Revealed Jasmonic Acid-Mediated Immune Responses of Potato (Antioxidants (Basel, Switzerland) · 2026Article
- Multi-genome comparative analysis and VIGS validation suggest thatFrontiers in plant science · 2026Article
- A tomato MAGIC population reveals candidate genes for leaf dry matter and phenolics, two key traits for stress resilience and climate-smart breeding.Frontiers in plant science · 2026Article
- Genome-wide identification and expression analysis reveals the drought-response MAPK genes in peanut (Arachis hypogaea L.).The plant genome · 2025Article
- Article
- Genome-wide identification and unveiling the role of MAP kinase cascade genes involved in sugarcane response to abiotic stressors.BMC plant biology · 2025Article
- Genome-wide screening of mitogen-activated protein kinase (MAPK) gene family and expression profile under heavy metal stress in Solanum lycopersicum.Biotechnology letters · 2025Article
- A genome-wide association study identified SNP markers and candidate genes associated with morphometric fruit quality traits in mangoes.BMC genomics · 2025Article
- Genome-wide identification and transcriptomic analysis of the MAPK family provides insights into the molecular basis of disease resistance of postharvest eggplant in response toFrontiers in plant science · 2025Article
- Characteristics of the MAPK gene family inJournal of genetics · 2025Article
- Consortia of3 Biotech · 2024Article
- Network analyses predict major regulators of resistance to early blight disease complex in tomato.BMC plant biology · 2024Article
- Surviving a Double-Edged Sword: Response of Horticultural Crops to Multiple Abiotic Stressors.International journal of molecular sciences · 2024Review
- Article
- Emerging Roles of Mitogen-Activated Protein Kinase Signaling Pathways in the Regulation of Fruit Ripening and Postharvest Quality.International journal of molecular sciences · 2024Review
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- Genome-wide identification ofFrontiers in genetics · 2024Article
- Identification and expression analysis of MAPK cascade gene family in foxtail millet (Plant signaling & behavior · 2023Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitogen-activated protein kinase (MAPK) cascades have important functions in plant growth, development, and response to various stresses. The MAPKK and MAPKKK gene families in tomato have never been systematically analyzed. In this study, we performed a genome-wide analysis of the MAPKK and MAPKKK gene families in tomato and identified 5 MAPKK genes and 89 MAPKKK genes. Phylogenetic analyses of the MAPKK and MAPKKK gene families showed that all the MAPKK genes formed four groups (groups A, B, C, and D), whereas all the MAPKKK genes were classified into three subfamilies, namely, MEKK, RAF, and ZIK. Evolutionary analysis showed that whole genome or chromosomal segment duplications were the main factors responsible for the expansion of the MAPKK and MAPKKK gene families in tomato. Quantitative real-time RT-PCR analysis showed that the majority of MAPKK and MAPKKK genes were expressed in all tested organs with considerable differences in transcript levels indicating that they might be constitutively expressed. However, the expression level of most of these genes changed significantly under heat, cold, drought, salt, and Pseudomonas syringae treatment. Furthermore, their expression levels exhibited significant changes in response to salicylic acid and indole-3-acetic acid treatment, implying that these genes might have important roles in the plant hormone network. Our comparative analysis of the MAPKK and MAPKKK families would improve our understanding of the evolution and functional characterization of MAPK cascades in tomato.
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