ArticleCell2014
Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility.
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in Cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 410 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
410citing papers in PubMed, 1 pooled it
31.2field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
410 citing papers in PubMed, 1 synthesis or guideline pooled it, 695 citations in OpenAlex.
- Pooled it
- Review
- A biomechanical model of inflammation-driven colon hypertrophy and dysmotility: Application to Gulf War Illness.Journal of the mechanical behavior of biomedical materials · 2026Article
- Reframing the Gut-Brain Axis: The Gut Wall as a Neural Immune Interface in Multiple Sclerosis and Autoimmune Neurological Diseases.Annals of neurology · 2026Review
- Prenatal exposure to environmental stressors alters gut macrophage development and gastrointestinal function of male offspring.Brain, behavior, and immunity · 2026Article
- Unraveling the Multifaceted Roles of Tissue-Resident Macrophages: Focus on Bone Homeostasis and Regeneration.Stem cell reviews and reports · 2026Review
- Phenotypic switching of gastrointestinal smooth muscle cells and the regulatory role of macrophages: a literature review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- The neurobiotic sense: emerging pathways of microbial detection and gut-brain communication.Pflugers Archiv : European journal of physiology · 2026Review
- Tissue-Resident Macrophages: Linking Physiology and Inflammation in Infection.Clinical reviews in allergy & immunology · 2026Review
- Macrophage-enteric nervous system crosstalk in Hirschsprung disease and associated enterocolitis: a focused narrative review with clinical implications.Pediatric surgery international · 2026Review
- The gut neuroepithelial unit as a neurodegeneration-relevant interface in the gut-brain axis.Translational neurodegeneration · 2026Review
- Gut instincts: Multi-level control and neural pathways involved in gastrointestinal interoception.Autonomic neuroscience : basic & clinical · 2026Review
- Microbial reactivation of host androgens directs enteric neuronal regulation of gut motility.Nature neuroscience · 2026Article
- CCR2-dependent monocytes gut-homing contributes to enteric neuroplastic changes in a mouse model of diet-induced obesity.Molecular medicine (Cambridge, Mass.) · 2026Article
- Intestinal muscularis in health and disease.Communications biology · 2026Review
- Exosomes derived from M1-macrophage promote enteric neuronal injury via MMP8-TGF-β pathway.Journal of advanced research · 2026Article
- C1qa muscularis macrophages maintain enteric synaptic homeostasis to regulate gastrointestinal motility.bioRxiv : the preprint server for biology · 2026Article
- Review
- Molecular and immunohistochemical characterization of intestinal macrophages subsets in goldfish.Scientific reports · 2026Article
- CD163 and Tim-4 identify resident intestinal macrophages that are spatially regulated by TGF-β.The Journal of experimental medicine · 2026Article
350 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
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- Erratum issuedDosage error in article text
Authors and funding
16 authors at 8 institutions in 1 country.
Paul Andrew MullerDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA; The Immunology Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA; Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA.
Balázs KoscsóDepartment of Microbiology and Immunology, Penn State University College of Medicine and Milton Hershey Medical Center, Hershey, PA 17033, USA.
Gaurav Manohar RajaniDepartment of Microbiology and Immunology, Penn State University College of Medicine and Milton Hershey Medical Center, Hershey, PA 17033, USA.
Korey StevanovicDepartment of Pediatrics, Morgan Stanley Children's Hospital, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
Marie-Luise BerresDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA; The Immunology Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA.
Daigo HashimotoDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA; The Immunology Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA.
Arthur MorthaDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA; The Immunology Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA.
Marylene LeboeufDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA; The Immunology Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA.
Xiu-Min LiDivision of Allergy and Immunology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA; Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA.
Daniel MucidaLaboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA.
E Richard StanleyDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Stephanie DahanThe Immunology Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA; Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA.
Kara Gross MargolisDepartment of Pediatrics, Morgan Stanley Children's Hospital, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
Michael David GershonDepartment of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
Miriam MeradDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA; The Immunology Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA. Electronic address: miriam.merad@mssm.edu.
Milena BogunovicDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA; The Immunology Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY 10029, USA; Department of Microbiology and Immunology, Penn State University College of Medicine and Milton Hershey Medical Center, Hershey, PA 17033, USA. Electronic address: mbogunovich@hmc.psu.edu.
Mount Sinai Hospital · USIcahn School of Medicine at Mount Sinai · USMorgan Stanley Children's Hospital · USMount Sinai Hospital · USPenn State Milton S. Hershey Medical Center · USAlbert Einstein College of Medicine · USColumbia University · USRockefeller University · US
Funding
WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI WINFRIED EDELMANN · 1985 to 2026
$111.2MMICROENVIRONMENT IN ENTERIC NEURON DEVELOPMENTR01NS015547 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GERSHON, MICHAEL D, MARGOLIS, KARA GROSS · 1985 to 2022
$7.2MERK control of Dendritic Cell Differentiation, Homeostasis and DiseaseR01CA154947 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CARL E ALLEN, MIRIAM MERAD · 2011 to 2026
$7.0MHEMOPOIETIC STEM CELL DIFFERENTIATION TO MACROPHAGESR01CA032551 · NCI · YESHIVA UNIVERSITY · PI STANLEY, E. RICHARD · 1985 to 2013
$5.4MPost-transcriptional regulation of the Dendritic Cell transcriptomeR01AI104848 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BROWN, BRIAN D, MERAD, MIRIAM · 2013 to 2017
$2.3MContribution of the cutaneous APC network to melanoma progression and therapy.R01CA173861 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MERAD, MIRIAM · 2013 to 2017
$2.1MRole of Mucosal DC Subsets in the Control of Influenza A Virus ImmunityU01AI095611 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MERAD, MIRIAM, PALUCKA, ANNA KAROLINA · 2011 to 2015
$1.8MEnteric Neuronal Development as a Determinant of Intestinal InflammationK08DK093786 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARGOLIS, KARA GROSS · 2013 to 2017
$781kIntegration of mucosal immune responses through the enteric nervous systemR21AI105047 · NIAID · ROCKEFELLER UNIVERSITY · PI MUCIDA, DANIEL S · 2013 to 2014
$466kNCI NIH HHS CA173861NCI NIH HHS CA32551NCI NIH HHS P30 CA013330NCI NIH HHS R01 CA032551NCI NIH HHS R01 CA154947NCI NIH HHS R01 CA173861NIAID NIH HHS AI09561NIAID NIH HHS AI104848NIAID NIH HHS R01 AI104848NIAID NIH HHS R21 AI105047NIAID NIH HHS R21-AI105047NIAID NIH HHS U01 AI095611NIDDK NIH HHS K08 DK093786NINDS NIH HHS R01 NS015547
Abstract
Intestinal peristalsis is a dynamic physiologic process influenced by dietary and microbial changes. It is tightly regulated by complex cellular interactions; however, our understanding of these controls is incomplete. A distinct population of macrophages is distributed in the intestinal muscularis externa. We demonstrate that, in the steady state, muscularis macrophages regulate peristaltic activity of the colon. They change the pattern of smooth muscle contractions by secreting bone morphogenetic protein 2 (BMP2), which activates BMP receptor (BMPR) expressed by enteric neurons. Enteric neurons, in turn, secrete colony stimulatory factor 1 (CSF1), a growth factor required for macrophage development. Finally, stimuli from microbial commensals regulate BMP2 expression by macrophages and CSF1 expression by enteric neurons. Our findings identify a plastic, microbiota-driven crosstalk between muscularis macrophages and enteric neurons that controls gastrointestinal motility. PAPERFLICK:
Indexed as
Gastrointestinal MotilityAnimalsBone Morphogenetic Protein 2Bone Morphogenetic Protein Receptors, Type IIGastrointestinal TractIn Vitro TechniquesMacrophage Colony-Stimulating FactorMacrophagesMiceNeuronsPeristalsisReceptor, Macrophage Colony-Stimulating FactorSignal TransductionBmp2 protein, mouseBone Morphogenetic Protein 2Bone Morphogenetic Protein Receptors, Type IIMacrophage Colony-Stimulating FactorReceptor, Macrophage Colony-Stimulating Factor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.