Evidence map›Paper›PMID 25036627›Full record

ArticleCell2014

γ-Secretase: a horseshoe structure brings good luck.

Michael S Wolfe, Dennis J Selkoe

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Membrane properties that shape the evolution of membrane enzymes.Current opinion in structural biology · 2018
    Review
  3. Nicastrin functions to sterically hinder γ-secretase-substrate interactions driven by substrate transmembrane domain.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  4. Fused Morphlinopyrimidines and Methods of Use Thereof.ACS medicinal chemistry letters · 2015
    Article
  5. Article
  6. The γ-secretase complex: from structure to function.Frontiers in cellular neuroscience · 2014
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Michael S WolfeCenter for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: mswolfe@partners.org.
Dennis J SelkoeCenter for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: dselkoe@partners.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intramembrane protease γ-secretase is a key player in signaling and Alzheimer's disease, but its structural features have remained obscure. A structure reported recently reveals a horseshoe-shaped arrangement of 19 transmembrane helices and an extracellular domain positioned for substrate recognition. This advance bodes well for a finer resolution before long.

Indexed as

Models, MolecularAmyloid Precursor Protein SecretasesHumansAmyloid Precursor Protein Secretases

Identifiers

PMID25036627

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.