Evidence map›Paper›PMID 25036625›Full record

ArticleCell2014

The contraction of time and space in remote chromosomal interactions.

Michael Levine

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Michael LevineDivision of Genetics, Genomics, and Development, Center for Integrative Genomics, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: mlevine@berkeley.edu.
Innovative Genomics Institute · US

Funding

SPATIAL REALMS OF HOMEOTIC GENE EXPRESSION IN DROSOPHILAR01GM034431 · NIGMS · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI LEVINE, MICHAEL STEVEN · 1985 to 2016
$4.4M
MOLECULAR CHARACTERIZATION OF THE DORSAL MORPHOGENR37GM046638 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI LEVINE, MICHAEL STEVEN · 2003 to 2012
$3.8M
Developmental Patterning of the Anterior Neural Plate in a Simple ChordateR01NS076542 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI LEVINE, MICHAEL STEVEN · 2012 to 2022
$3.4M
MOLECULAR CHARACTERIZATION OF THE DORSAL MORPHOGENR01GM046638 · NIGMS · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI LEVINE, MICHAEL STEVEN · 1991 to 2016
$2.3M
NIGMS NIH HHS R01 GM034431NIGMS NIH HHS R01 GM046638NIGMS NIH HHS R37 GM046638NINDS NIH HHS R01 NS076542
6 · The paper itself

Abstract

Lucas et al. report the visualization of V(D)J recombination of the immunoglobulin heavy-chain gene (Igh) in living pro-B cells. Despite the huge distances separating V coding sequences from D-J sequences (~2 Mb), the authors document an astonishingly rapid rate of remote associations. The key to speed is contraction of the Igh chromosomal domain. These findings provide a foundation for understanding long-range regulatory interactions in a variety of developmental processes, including the patterning of vertebrate limbs.

Indexed as

V(D)J RecombinationAnimalsImmunoglobulin Heavy ChainsImmunoglobulin Heavy Chains

Identifiers

PMID25036625
PMCPMC4258836
OpenAlexW2080551755

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.