Evidence map›Paper›PMID 25036340›Full record

ArticleVirology2014

Each of the eight simian hemorrhagic fever virus minor structural proteins is functionally important.

Heather A Vatter, Han Di, Eric F Donaldson, Ralph S Baric, Margo A Brinton

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

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  8. Expanded subgenomic mRNA transcriptome and coding capacity of a nidovirus.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
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4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Heather A VatterDepartment of Biology, Georgia State University, Atlanta, GA 30303, United States.
Han DiDepartment of Biology, Georgia State University, Atlanta, GA 30303, United States.
Eric F DonaldsonDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Ralph S BaricDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Margo A BrintonDepartment of Biology, Georgia State University, Atlanta, GA 30303, United States. Electronic address: mbrinton@gsu.edu.
Georgia State University · USUniversity of North Carolina at Chapel Hill · US

Funding

Yessinia autotransporters (Yaps): Structure, function, and host responseU54AI057157 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SPARLING, PHILIP FREDERICK · 2003 to 2013
$91.4M
Development of a new model of viral hemorrhagic fever. R21AI073824 · NIAID · GEORGIA STATE UNIVERSITY · PI BRINTON, MARGO A · 2007 to 2008
$358k
NIAID NIH HHS AI073824NIAID NIH HHS R21 AI073824NIAID NIH HHS U54 AI057157NIAID NIH HHS U54-AI057157PI
6 · The paper itself

Abstract

The simian hemorrhagic fever virus (SHFV) genome differs from those of other members of the family Arterivirus in encoding two adjacent sets of four minor structural protein open reading frames (ORFs). A stable, full-length, infectious SHFV-LVR cDNA clone was constructed. Virus produced from this clone had replication characteristics similar to those of the parental virus. A subgenomic mRNA was identified for the SHFV ORF previously identified as 2b. As an initial means of analyzing the functional relevance of each of the SHFV minor structural proteins, a set of mutant infectious clones was generated, each with the start codon of one minor structural protein ORF mutated. Different phenotypes were observed for each ortholog of the pairs of minor glycoproteins and all of the eight minor structural proteins were required for the production of infectious extracellular virus indicating that the duplicated sets of SHFV minor structural proteins are not functionally redundant.

Indexed as

Virus ReplicationAnimalsArterivirusCell LineChlorocebus aethiopsCodon, InitiatorMutationViral Structural ProteinsCodon, InitiatorViral Structural ProteinsInfectious cloneMinor structural proteinsSimian hemorrhagic fever virusSubgenomic mRNAs

Identifiers

PMID25036340
PMCPMC4128006
OpenAlexW2004300620

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.