ArticleDevelopment and psychopathology2015
Prenatal cocaine exposure differentially affects stress responses in girls and boys: associations with future substance use.
Article in Development and psychopathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Adrenocortical and autonomic cross-system regulation in youth: A meta-analysis.Psychoneuroendocrinology · 2024Pooled it
- Laboratory and Real-World Experimental Approaches to Understanding Alcohol Relapse.Current topics in behavioral neurosciences · 2025Review
- The Dopamine System in Mediating Alcohol Effects in Humans.Current topics in behavioral neurosciences · 2025Review
- Stress and substance use disorders: risk, relapse, and treatment outcomes.The Journal of clinical investigation · 2024Review
- Prenatal Substance Exposure.Annual review of developmental psychology · 2023Article
- Sex differences in emotion- and reward-related neural responses predicting increases in substance use in adolescence.Behavioural brain research · 2023Article
- Prenatal substance exposure, early-life adversity, and parenting: Associations with adolescent stress response.Developmental psychobiology · 2023Article
- Influence of Prevalence of Psychoactive Substance Use in Mexican Municipalities on Early Childhood Development.International journal of environmental research and public health · 2021Article
- The Role of Stress, Trauma, and Negative Affect in Alcohol Misuse and Alcohol Use Disorder in Women.Alcohol research : current reviews · 2020Review
- Prenatal drug exposure and neurodevelopmental programming of glucocorticoid signalling.Journal of neuroendocrinology · 2020Review
- Sex-Differentiated Associations among Negative Parenting, Emotion-Related Brain Function, and Adolescent Substance Use and Psychopathology Symptoms.Social development (Oxford, England) · 2019Article
- Prenatal drug exposure from infancy through emerging adulthood: Results from neuroimaging.Drug and alcohol dependence · 2019Review
- Maternal Emotional and Physiological Reactivity: Implications for Parenting and the Parenting-Adolescent Relationship.Journal of child and family studies · 2019Article
- Neuroendocrine and immune pathways from pre- and perinatal stress to substance abuse.Neurobiology of stress · 2018Review
- Stress reactivity and the developmental psychopathology of adolescent substance use.Neurobiology of stress · 2018Review
- Central and Peripheral Biomarkers of Stress Response for Addiction Risk and Relapse Vulnerability.Trends in molecular medicine · 2018Review
- Altered functional connectivity to stressful stimuli in prenatally cocaine-exposed adolescents.Drug and alcohol dependence · 2017Article
- Childhood adversity interacts with adult stressful events to predict reduced likelihood of smoking cessation among women but not men.Clinical psychological science : a journal of the Association for Psychological Science · 2016Article
- Developmental Pathways from Prenatal Substance Exposure to Reactive Aggression.Journal of applied developmental psychologyArticle
- Longitudinal changes of amygdala and default mode activation in adolescents prenatally exposed to cocaine.Neurotoxicology and teratologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Prenatal cocaine exposure may affect developing stress response systems in youth, potentially creating risk for substance use in adolescence. Further, pathways from prenatal risk to future substance use may differ for girls versus boys. The present longitudinal study examined multiple biobehavioral measures, including heart rate, blood pressure, emotion, and salivary cortisol and salivary alpha amylase (sAA), in response to a stressor in 193 low-income 14- to 17-year-olds, half of whom were prenatally cocaine exposed (PCE). Youth's lifetime substance use was assessed with self-report, interview, and urine toxicology/breathalyzer at Time 1 and at Time 2 (6-12 months later). PCE × Gender interactions were found predicting anxiety, anger, and sadness responses to the stressor, with PCE girls showing heightened responses as compared to PCE boys on these indicators. Stress Response × Gender interactions were found predicting Time 2 substance use in youth (controlling for Time 1 use) for sAA and sadness; for girls, heightened sadness responses predicted substance use, but for boys, dampened sAA responses predicted substance use. Findings suggest distinct biobehavioral stress response risk profiles for boys and girls, with heightened arousal for girls and blunted arousal for boys associated with prenatal risk and future substance use outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.