ArticleJournal of biomedical optics2014
Assessment of microcirculation dynamics during cutaneous wound healing phases in vivo using optical microangiography.
Article in Journal of biomedical optics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Characterization of oral biomarkers during early healing at augmented dental implant sites.Journal of periodontal research · 2025Trial
- Doppler ultrasonographic evaluation of tissue revascularization following connective tissue graft at implant sites.Journal of clinical periodontology · 2025Trial
- Intraoperative intravenous infusion of lidocaine increases total and small vessel densities of sublingual microcirculation: a randomized prospective pilot study.The Journal of international medical research · 2023Trial
- Tissue perfusion and its influencing factors in epigastrial adipocutanous flaps affected by ischemia-reperfusion in rats.Acta cirurgica brasileira · 2026Article
- Skin layer-specific spatiotemporal assessment of micrometabolism during wound angiogenesis.Communications biology · 2024Article
- Topical application of a hyaluronic acid-based hydrogel integrated with secretome of human mesenchymal stromal cells for diabetic ulcer repair.Regenerative therapy · 2024Article
- Photoacoustic microscopy of vascular adaptation and tissue oxygen metabolism during cutaneous wound healing.Biomedical optics express · 2022Article
- Label-free concurrent 5-modal microscopy (Co5M) resolves unknown spatio-temporal processes in wound healing.Communications biology · 2021Article
- Ultrasonographic tissue perfusion analysis at implant and palatal donor sites following soft tissue augmentation: A clinical pilot study.Journal of clinical periodontology · 2021Article
- Automatic skin lesion area determination of basal cell carcinoma using optical coherence tomography angiography and a skeletonization approach: Preliminary results.Journal of biophotonics · 2019Article
- Microvascular imaging of the skin.Physics in medicine and biology · 2019Review
- Multifunctional in vivo imaging for monitoring wound healing using swept-source polarization-sensitive optical coherence tomography.Lasers in surgery and medicine · 2018Article
- Optical coherence tomography angiography monitors human cutaneous wound healing over time.Quantitative imaging in medicine and surgery · 2018Article
- Noninvasive assessment of cutaneous alterations in mice exposed to whole body gamma irradiation using optical imaging techniques.Lasers in medical science · 2017Article
- Retooling Laser Speckle Contrast Analysis Algorithm to Enhance Non-Invasive High Resolution Laser Speckle Functional Imaging of Cutaneous Microcirculation.Scientific reports · 2017Article
- Potential use of OCT-based microangiography in clinical dermatology.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2016Article
- Accessing to arteriovenous blood flow dynamics response using combined laser speckle contrast imaging and skin optical clearing.Biomedical optics express · 2015Article
- High resolution imaging of acne lesion development and scarring in human facial skin using OCT-based microangiography.Lasers in surgery and medicine · 2015Article
- Segmentation and quantification of blood vessels for OCT-based micro-angiograms using hybrid shape/intensity compounding.Microvascular research · 2015Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cutaneous wound healing consists of multiple overlapping phases starting with blood coagulation following incision of blood vessels. We utilized label-free optical coherence tomography and optical microangiography (OMAG) to noninvasively monitor healing process and dynamics of microcirculation system in a mouse ear pinna wound model. Mouse ear pinna is composed of two layers of skin separated by a layer of cartilage and because its total thickness is around 500 μm, it can be utilized as an ideal model for optical imaging techniques. These skin layers are identical to human skin structure except for sweat ducts and glands. Microcirculatory system responds to the wound injury by recruiting collateral vessels to supply blood flow to hypoxic region. During the inflammatory phase, lymphatic vessels play an important role in the immune response of the tissue and clearing waste from interstitial fluid. In the final phase of wound healing, tissue maturation, and remodeling, the wound area is fully closed while blood vessels mature to support the tissue cells. We show that using OMAG technology allows noninvasive and label-free monitoring and imaging each phase of wound healing that can be used to replace invasive tissue sample histology and immunochemistry technologies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.