ArticleImmunity2014
Futility sustains memory T cells.
Article in Immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Metabolic rewiring of the dendritic cell-T cell axis: tumour-derived barriers and therapeutic opportunities.Experimental & molecular medicine · 2026Review
- Unveiling fatty acid subtypes: immunometabolic interplay and therapeutic opportunities in gastric cancer.Frontiers in oncology · 2025Article
- Regulatory Mechanisms and Reversal of CD8Biology · 2023Review
- Mitochondria Need Their Sleep: Redox, Bioenergetics, and Temperature Regulation of Circadian Rhythms and the Role of Cysteine-Mediated Redox Signaling, Uncoupling Proteins, and Substrate Cycles.Antioxidants (Basel, Switzerland) · 2023Article
- Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response.Cell reports · 2021Article
- Fat for fuel: lipid metabolism in haematopoiesis.Clinical & translational immunology · 2019Review
- Early Inhibition of Fatty Acid Synthesis Reduces Generation of Memory Precursor Effector T Cells in Chronic Infection.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Obesity altered T cell metabolism and the response to infection.Current opinion in immunology · 2017Review
- Article
- Metabolomics connects aberrant bioenergetic, transmethylation, and gut microbiota in sarcoidosis.Metabolomics : Official journal of the Metabolomic Society · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Memory T cells display a distinct metabolic profile compared to effector T cells. In this issue of Immunity, O'Sullivan et al. (2014) report that memory T cells activate a "futile cycle" of de novo fatty-acid synthesis and concurrent fatty-acid oxidation to generate ATP for cell survival.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.