ArticleInternational journal of clinical and experimental medicine2014
Expressional analysis of p16 and cytokeratin19 protein in the genesis of oral squamous cell carcinoma patients.
Article in International journal of clinical and experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Modulation of cytokeratin and cytokine/chemokine expression following influenza virus infection of differentiated human tonsillar epithelial cells.Journal of virology · 2025Article
- p53, Cytokeratin 19 Expression in Oral Squamous Cell Carcinoma and Correlation with Histopathologic Grading: An Immunohistochemical Study.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Article
- Clinical implications of Cytokeratin 19 expression in patients with oral squamous cell carcinoma.Pathologica · 2023Article
- Cytokeratin 7 and 19 expression in oropharyngeal and oral squamous cell carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Article
- Assessment of Expression of Ki-67 in Benign and Malignant Prostatic Lesions among Sudanese Patients.Open access Macedonian journal of medical sciences · 2018Article
- Relationship between CK19 expression, deregulation of normal keratinocyte differentiation pattern and high risk-human papilloma virus infection in oral and oropharyngeal squamous cell carcinoma.Infectious agents and cancer · 2015Article
- Review on molecular and chemopreventive potential of nimbolide in cancer.Genomics & informatics · 2014Review
- Curcumin: a potential candidate in prevention of cancer via modulation of molecular pathways.BioMed research international · 2014Review
- Evaluation of p16 expression in oral and oropharyngeal squamous cell carcinoma.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
p16 is a cell cycle inhibitor that is frequently inactivated in various types of tumours. In spite of p16 importance and its association with clinical behaviour in the genesis of Oral Squamous Cell Carcinoma (OSCC) is not understood fully. The aim of study was to examine the impact of p16 and CK19 in the development and progression of tumour with other clinical behaviours. In the present study, expression profiles of p16 and Cytokeratin19 (CK19) protein were analysed through immunohistochemistry using anti-p16 and anti-CK19 antibody. Expressions pattern of p16 and CK19 were noticed 40% and 58% in the OSCC respectively. Whereas expressions pattern were different in control cases for both markers as p16 (70%) and CK19 (20%). There was progressive loss of p16 expression from oral inflammatory lesion to OSCC and this differences were statically significant (p<0.05). The positivity of p16 were observed in gender where its expression pattern did not reach statistical significance (p>0.05). Expression pattern of CK19 were observed and its expression increased according to the grade and stage of cancer. Furthermore, CK19 expression was seen to be significantly higher in male in the age group ≥50 years (p<0.05). This finding shows that p16 and CK19 may have potential as a prognostic marker in human OSCC and important molecular event in pathogenesis of oral carcinoma.
Indexed as
Identifiers
25035775PMC4100961W1460266873What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.