ArticlePharmacy practice2014
Assessing the adherence to and the therapeutic effectiveness of hypolipidemic agents in a population of patients in Brazil: a retrospective cohort study.
Article in Pharmacy practice, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Lipid-lowering drug prescriptions in a group of Colombian patients.Biomedica : revista del Instituto Nacional de Salud · 2019Article
- The influence of cultural and religious orientations on social support and its potential impact on medication adherence.Patient preference and adherence · 2015Article
- Interventional tools to improve medication adherence: review of literature.Patient preference and adherence · 2015Review
- Effects of simvastatin and atorvastatin on biochemical and hematological markers in patients with risk of cardiovascular diseases.International journal of clinical and experimental medicine · 2015Article
- Adherence to prescribed medications of Iranian traditional medicine in a group of patients with chronic disease.Journal of research in pharmacy practiceArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveto evaluate the relation between patient adherence and therapeutic effectiveness of hypolipidemic agents in clinical practice.
methodsA retrospective cohort study of 417 patients using hypolipidemic drugs (simvastatin, atorvastatin) between 2003 and 2010 was performed. The population studied consists of patients assisted by the Public Health Service in the far-west region of the State of Santa Catarina, Brazil. The Medication Possession Ratio obtained from pharmacy refill data was used to measure patient adherence. Therapeutic effectiveness was evaluated based on the difference obtained in the serum levels of total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides, before and after taking the drug, in an average time of 8.3 months.
resultsFollowing the treatment with hypolipidemic agents, it has been observed a reduction of 14.3% for total cholesterol, 19.6% for LDL-cholesterol, and 14.4% for triglycerides. HDL-cholesterol increased by an 8.0% average. The major changes in lipid profile were promoted by atorvastatin 20 mg daily. The medication adherence rate decreased over the monitoring period. Adherence rates below 60% were associated with therapeutic failure, while rates equal to 80% or higher were associated with the best response to the lipid-lowering drugs.
conclusionAdherence to hypolipidemic agents is higher at the beginning of the treatment, but it decreases over time, affecting the achievement of therapeutic goals.
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