ArticleGenes & development2014
Multiple FLC haplotypes defined by independent cis-regulatory variation underpin life history diversity in Arabidopsis thaliana.
Article in Genes & development, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed.
- Molecular integration of seasonal temperature signals in flowering time control.Nature reviews. Genetics · 2026Review
- Temperature regulation in plants: From molecular mechanisms to climate-resilient crop improvement.Journal of integrative plant biology · 2026Review
- Co-transcriptional splicing changes combine with reduced productive transcription initiation for cold-induced repression of FLC.Nucleic acids research · 2026Article
- Gene body methylation regulates gene expression and mediates phenotypic diversity in natural Arabidopsis populations.Nature plants · 2025Article
- Species-wide gene editing of a flowering regulator reveals hidden phenotypic variation.PLoS biology · 2025Article
- All roads lead to Rome: QTL analysis for vernalization requirement and dissection of allelic variation uncovered unexpected diversity ofFrontiers in plant science · 2025Article
- Flowering time: From physiology, through genetics to mechanism.Plant physiology · 2024Review
- Responsiveness to long days for flowering is reduced in Arabidopsis by yearly variation in growing season temperatures.Plant, cell & environment · 2023Article
- Artificial selection reveals complex genetic architecture of shoot branching and its response to nitrate supply in Arabidopsis.PLoS genetics · 2023Article
- Pan-European study of genotypes and phenotypes in the Arabidopsis relative Cardamine hirsuta reveals how adaptation, demography, and development shape diversity patterns.PLoS biology · 2023Article
- Upregulation of tandem duplicated BoFLC1 genes is associated with the non-flowering trait in Brassica oleracea var. capitata.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Parental methylation mediates how progeny respond to environments of parents and of progeny themselves.Annals of botany · 2022Article
- A 215-bp indel at intron I of BoFLC2 affects flowering time in Brassica oleracea var. capitata during vernalization.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Global Genetic Heterogeneity in Adaptive Traits.Molecular biology and evolution · 2021Article
- Revisiting a GWAS peak in Arabidopsis thaliana reveals possible confounding by genetic heterogeneity.Heredity · 2021Article
- Natural temperature fluctuations promoteGenes & development · 2021Article
- Beyond the Genetic Pathways, Flowering Regulation Complexity inInternational journal of molecular sciences · 2021Review
- Diversity and selection of the continuous-flowering gene, RoKSN, in rose.Horticulture research · 2021Article
- Total FLC transcript dynamics from divergent paralogue expression explains flowering diversity in Brassica napus.The New phytologist · 2021Article
- Gene regulatory networks controlled by FLOWERING LOCUS C that confer variation in seasonal flowering and life history.Journal of experimental botany · 2021Article
6 more citing papers are in PubMed but not listed here.
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11 authors.
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Abstract
Relating molecular variation to phenotypic diversity is a central goal in evolutionary biology. In Arabidopsis thaliana, FLOWERING LOCUS C (FLC) is a major determinant of variation in vernalization--the acceleration of flowering by prolonged cold. Here, through analysis of 1307 A. thaliana accessions, we identify five predominant FLC haplotypes defined by noncoding sequence variation. Genetic and transgenic experiments show that they are functionally distinct, varying in FLC expression level and rate of epigenetic silencing. Allelic heterogeneity at this single locus accounts for a large proportion of natural variation in vernalization that contributes to adaptation of A. thaliana.
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