ArticleThe Plant cell2014
DELLAs function as coactivators of GAI-ASSOCIATED FACTOR1 in regulation of gibberellin homeostasis and signaling in Arabidopsis.
Article in The Plant cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.
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102 citing papers in PubMed, 230 citations in OpenAlex.
- DELLA proteins interact with HAC1 and control plant growth via transcriptional regulation of the growth repressor gene ERF2.The Plant cell · 2026Article
- Integrated metabolomic-transcriptomic profiling of dwarf Camellia reticulata 'Hentiangao' reveals key gibberellin metabolism genes and multi-hormone crosstalk under GABMC plant biology · 2026Article
- Genome-wide identification and expression analysis of IDD gene family in Gossypium hirsutum L.Functional & integrative genomics · 2026Article
- Mevalonate kinase represses anthocyanin biosynthesis via sucrose transporters and gibberellin synthesis pathways in arabidopsis.Plant cell reports · 2026Article
- Genome-Wide Identification of theGenes · 2026Article
- The Structure, Classification, Functional Diversity and Regulatory Mechanism of Plant C2H2 Transcription Factors.Biology · 2026Review
- INDETERMINATE DOMAIN-DELLA protein interactions orchestrate gibberellin-mediated cell elongation in wheat and barley.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The multifaceted role of gibberellins in somatic embryogenesis: fromFrontiers in plant science · 2026Review
- Editing a gibberellin receptor gene improves yield and nitrogen fixation in soybean.Journal of integrative plant biology · 2026Article
- Gibberellin pathway remodeling accompanies ethylene-driven sex reversal inFrontiers in plant science · 2026Article
- From binding to networks: methods for identifying transcription factor targets in plant systems.Frontiers in plant science · 2026Review
- MEVALONATE KINASE represses anthocyanin biosynthesis via sucrose transporters and gibberellin synthesis pathways in Arabidopsis.Research square · 2025Article
- "Bud to bloom"-hormonal coordination in floral initiation.Plant biology (Stuttgart, Germany) · 2025Review
- AraceaeDB: a functional genomics database of the Araceae family with a focus on konjac glucomannan biosynthesis inHorticulture research · 2025Article
- A mobile DELLA controls Medicago truncatula root cortex patterning to host arbuscular mycorrhizal fungi.Nature plants · 2025Article
- Genome-Wide Identification of theGenes · 2025Article
- Structural insights into proteolysis-dependent and -independent suppression of the master regulator DELLA by the gibberellin receptor.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Transcriptional corepressor OsTPR1 regulates tillering and lateral root development in rice.Scientific reports · 2025Article
- Identification of DELLA and GID1 genes in Catharanthus roseus and their potential role in regulating vindoline biosynthesis.Plant molecular biology · 2025Article
- Overexpression of SiICE2 gene reduces plant height and increases yield in cotton (Gossypium hirsutum).BMC plant biology · 2025Article
42 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gibberellins (GAs) are essential regulators of plant development, and DELLAs are negative regulators of GA signaling. The mechanism of GA-dependent transcription has been explained by DELLA-mediated titration of transcriptional activators and their release through the degradation of DELLAs in response to GA. However, the effect of GA on genome-wide expression is predominantly repression, suggesting the existence of unknown mechanisms of GA function. In this study, we identified an Arabidopsis thaliana DELLA binding transcription factor, GAI-ASSOCIATED FACTOR1 (GAF1). GAF1 shows high homology to INDETERMINATE DOMAIN1 (IDD1)/ENHYDROUS. GA responsiveness was decreased in the double mutant gaf1 idd1, whereas it was enhanced in a GAF1 overexpressor. GAF1 binds to genes that are subject to GA feedback regulation. Furthermore, we found that GAF1 interacts with the corepressor TOPLESS RELATED (TPR) and that DELLAs and TPR act as coactivators and a corepressor of GAF1, respectively. GA converts the GAF1 complex from transcriptional activator to repressor via the degradation of DELLAs. These results indicate that DELLAs turn on or off two sets of GA-regulated genes via dual functions, namely titration and coactivation, providing a mechanism for the integrative regulation of plant growth and GA homeostasis.
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