ArticleArteriosclerosis, thrombosis, and vascular biology2014
Transmembrane protein 55B is a novel regulator of cellular cholesterol metabolism.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Loss of TMEM55B modulates lipid metabolism through dysregulated lipophagy and mitochondrial function.Cell death & disease · 2026Article
- [Neurospecific transmembrane protein 240 colocalizes with peroxisomes and activates Rho GDP dissociation inhibitor β].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- Hepatic retinol dehydrogenase 11 dampens stress associated with the maintenance of cellular cholesterol levels.Molecular metabolism · 2024Article
- Hippocampal TMEM55B overexpression in the 5XFAD mouse model of Alzheimer's disease.Hippocampus · 2024Article
- Evaluation of obstructive sleep apnea: an analysis based on aberrant genes.Sleep & breathing = Schlaf & Atmung · 2023Article
- Mechanism of the Regulation of Plasma Cholesterol Levels by PI(4,5)PAdvances in experimental medicine and biology · 2023Article
- Crosstalk Between Cholesterol, ABC Transporters, and PIP2 in Inflammation and Atherosclerosis.Advances in experimental medicine and biology · 2023Article
- Expression patterns and the roles of phosphatidylinositol phosphatases in testis†.Biology of reproduction · 2022Article
- Striking a balance: PIPExploration of neuroprotective therapy · 2021Article
- Development of a Four-mRNA Expression-Based Prognostic Signature for Cutaneous Melanoma.Frontiers in genetics · 2021Article
- Phosphatidylinositol-(4,5)-Bisphosphate Regulates Plasma Cholesterol Through LDL (Low-Density Lipoprotein) Receptor Lysosomal Degradation.Arteriosclerosis, thrombosis, and vascular biology · 2020Article
- GeneFishing to reconstruct context specific portraits of biological processes.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes.Nature communications · 2017Article
- Chronic Cigarette Smoke Mediated Global Changes in Lung Mucoepidermoid Cells: A Phosphoproteomic Analysis.Omics : a journal of integrative biology · 2017Article
- PI(4,5)P2 Is Translocated by ABCA1 to the Cell Surface Where It Mediates Apolipoprotein A1 Binding and Nascent HDL Assembly.Circulation research · 2016Article
- SUGP1 is a novel regulator of cholesterol metabolism.Human molecular genetics · 2016Article
- RP1-13D10.2 Is a Novel Modulator of Statin-Induced Changes in Cholesterol.Circulation. Cardiovascular genetics · 2016Article
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveInterindividual variation in pathways affecting cellular cholesterol metabolism can influence levels of plasma cholesterol, a well-established risk factor for cardiovascular disease. Inherent variation among immortalized lymphoblastoid cell lines from different donors can be leveraged to discover novel genes that modulate cellular cholesterol metabolism. The objective of this study was to identify novel genes that regulate cholesterol metabolism by testing for evidence of correlated gene expression with cellular levels of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) mRNA, a marker for cellular cholesterol homeostasis, in a large panel of lymphoblastoid cell lines. APPROACH AND
resultsExpression array profiling was performed on 480 lymphoblastoid cell lines established from participants of the Cholesterol and Pharmacogenetics (CAP) statin clinical trial, and transcripts were tested for evidence of correlated expression with HMGCR as a marker of intracellular cholesterol homeostasis. Of these, transmembrane protein 55b (TMEM55B) showed the strongest correlation (r=0.29; P=4.0E-08) of all genes not previously implicated in cholesterol metabolism and was found to be sterol regulated. TMEM55B knockdown in human hepatoma cell lines promoted the decay rate of the low-density lipoprotein receptor, reduced cell surface low-density lipoprotein receptor protein, impaired low-density lipoprotein uptake, and reduced intracellular cholesterol.
conclusionsHere, we report identification of TMEM55B as a novel regulator of cellular cholesterol metabolism through the combination of gene expression profiling and functional studies. The findings highlight the value of an integrated genomic approach for identifying genes that influence cholesterol homeostasis.
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