ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2014
Use of influenza antiviral agents by ambulatory care clinicians during the 2012-2013 influenza season.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
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Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prevalence and healthcare burden of inappropriate antimicrobial treatment in patients at high risk of complications from acute respiratory infections: a scoping review.Frontiers in medicine · 2025Pooled it
- Health care costs of influenza-related episodes in high income countries: A systematic review.PloS one · 2018Pooled it
- Synergistic Alleviation of Inflammatory Cytokine Storms in Sepsis Rats by Low-Intensity Pulsed Ultrasound and Imipenem.Mediators of inflammation · 2026Article
- Patterns in Prescribing and Dispensing Influenza Antivirals Among Adults With Influenza Presenting to Urgent Care and Emergency Department Settings: VISION Network, 2023-2024.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Article
- Factors Associated with Antiviral Drug Use Among Commercially Insured Children at High Risk for Complications of Influenza.The Journal of pediatrics · 2025Article
- Antiviral Prescription in Children With Influenza in US Emergency Departments: New Vaccine Surveillance Network (NVSN), 2016-2020.Influenza and other respiratory viruses · 2025Article
- Snowball Group Usability Testing for Rapid and Iterative Multisite Tool Development: Method Development Study.JMIR formative research · 2025Article
- Perceptions and Barriers to Outpatient Antiviral Therapy for COVID-19 and Influenza as Observed by Infectious Disease Specialists in North America: Results of an Emerging Infections Network (EIN) Survey, February 2024.Open forum infectious diseases · 2024Article
- Factors Associated With Nonprescription of Oseltamivir for Infant Influenza Over 9 Seasons.Journal of the Pediatric Infectious Diseases Society · 2024Article
- Barriers to Implementing Registered Nurse-Driven Clinical Decision Support for Antibiotic Stewardship: Retrospective Case Study.JMIR formative research · 2024Article
- Ambulatory antibiotic prescription rates for acute respiratory infection rebound two years after the start of the COVID-19 pandemic.PloS one · 2024Article
- Reducing prescribing of antibiotics for acute respiratory infections using a frontline nurse-led EHR-Integrated clinical decision support tool: protocol for a stepped wedge randomized control trial.BMC medical informatics and decision making · 2023Article
- Antiviral Prescribing Among Patients at an Ambulatory Cancer Center With Laboratory-Confirmed Influenza.Open forum infectious diseases · 2023Article
- Guideline-Concordant Antiviral Treatment in Children at High Risk for Influenza Complications.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Seasonal influenza in children: Costs for the health system and society in Europe.Influenza and other respiratory viruses · 2022Review
- Real-World Use of Molnupiravir in the Treatment of Outpatients with SARS-CoV-2 Infection-A Patient Profile Based on the Experience of a Tertiary Infectious Disease Center.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Improved Influenza Diagnostics through Thermal Contrast Amplification.Diagnostics (Basel, Switzerland) · 2021Article
- Rate of use and effectiveness of oseltamivir in the treatment of influenza illness in high-risk populations: A systematic review and meta-analysis.Health science reports · 2021Article
- Optimizing Use of Antibiotics and Antivirals in Ambulatory Patients With Influenza.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Reducing Antibiotic Use in Ambulatory Care Through Influenza Vaccination.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
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Abstract
backgroundEarly antiviral treatment (≤2 days since illness onset) of influenza reduces the probability of influenza-associated complications. Early empiric antiviral treatment is recommended for those with suspected influenza at higher risk for influenza complications regardless of their illness severity. We describe antiviral receipt among outpatients with acute respiratory illness (ARI) and antibiotic receipt among patients with influenza.
methodsWe analyzed data from 5 sites in the US Influenza Vaccine Effectiveness Network Study during the 2012-2013 influenza season. Subjects were outpatients aged ≥6 months with ARI defined by cough of ≤7 days' duration; all were tested for influenza by polymerase chain reaction (PCR). Medical history and prescription information were collected by medical and pharmacy records. Four sites collected prescribing data on 3 common antibiotics (amoxicillin-clavulanate, amoxicillin, and azithromycin).
resultsOf 6766 enrolled ARI patients, 509 (7.5%) received an antiviral prescription. Overall, 2366 (35%) had PCR-confirmed influenza; 355 (15%) of those received an antiviral prescription. Among 1021 ARI patients at high risk for influenza complications (eg, aged <2 years or ≥65 years or with ≥1 chronic medical condition) presenting to care ≤2 days from symptom onset, 195 (19%) were prescribed an antiviral medication. Among participants with PCR-confirmed influenza and antibiotic data, 540 of 1825 (30%) were prescribed 1 of 3 antibiotics; 297 of 1825 (16%) were prescribed antiviral medications.
conclusionsAntiviral treatment was prescribed infrequently among outpatients with influenza for whom therapy would be most beneficial; in contrast, antibiotic prescribing was more frequent. Continued efforts to educate clinicians on appropriate antibiotic and antiviral use are essential to improve healthcare quality.
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