ArticleForensic science, medicine, and pathology2014
Diagnostic performance of urinary metanephrines for the postmortem diagnosis of hypothermia.
Article in Forensic science, medicine, and pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 21 citations in OpenAlex.
- Reverse Wischnewsky spots: a novel visual presentation of the traditional autopsy sign.Forensic science, medicine, and pathology · 2026Article
- Metabolomic analysis of fatal hypothermia using ultra-high-performance liquid chromatography‒mass spectrometry.Frontiers in molecular biosciences · 2025Article
- Factors Influencing Postmortem Catecholamine Level and Its Correlations With Agony Time and Cause of Death in Medicolegal Autopsy.Journal of Korean medical science · 2023Article
- Takotsubo cardiomyopathy developed during rewarming of accidental hypothermia with extracorporeal membrane oxygenation.Acute medicine & surgery · 2019Article
- Determination of urinary catecholamines and metanephrines in cardiac deaths.International journal of legal medicine · 2016Article
- Catecholamines and their O-methylated metabolites in vitreous humor in hypothermia cases.Forensic science, medicine, and pathology · 2016Article
- A case of suicide by self-injection of adrenaline.Forensic science, medicine, and pathology · 2015Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to assess the diagnostic potential of urinary metanephrines and 3-methoxytyramine compared to urinary catecholamine determination in diagnosing antemortem cold exposure and fatal hypothermia. 83 cases of fatal hypothermia and 144 control cases were included in this study. Catecholamines (adrenaline, noradrenaline and dopamine), metanephrines (metanephrine, normetanephrine) and 3-methoxytyramine were measured in urine collected during autopsy. All tested analytes were significantly higher in hypothermia cases compared to control subjects and displayed a generally satisfying discriminative value, thus indicating urinary catecholamines and their metabolites as reliable markers of cold-related stress and hypothermia related-deaths. Metanephrine and adrenaline had the best discriminative value between hypothermia and control cases compared to other tested analytes, though with different sensitivity and specificity. These can therefore be considered the most suitable markers of cold-related stress.
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