ArticleWorld journal of surgical oncology2014
Application of intraoperative frozen section examination in the management of female breast cancer in China: a nationwide, multicenter 10-year epidemiological study.
Article in World journal of surgical oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- Trial
- Fluorescence imaging of sentinel lymph nodes in breast cancer: a bibliometric analysis of global research trends (2000-2025).Gland surgery · 2026Article
- Exploratory multi-cohort, multi-reader study on the clinical utility of a deep learning model for transforming cryosectioned to formalin-fixed, paraffin-embedded (FFPE) images in breast lesion diagnosis.Breast cancer research : BCR · 2025Article
- Comparison of staining quality between rapid and routine hematoxylin and eosin staining of frozen breast tissue sections: an observational study.The Journal of international medical research · 2024Observational
- An intraoperative nomogram for predicting secondary margin positivity in breast conserving surgery utilizing frozen section analysis.Frontiers in oncology · 2024Article
- Application of near-infrared fluorescence imaging in the accurate assessment of surgical margins during breast-conserving surgery.World journal of surgical oncology · 2022Article
- How accurate is frozen section pathology compared to permanent pathology in detecting involved margins and lymph nodes in breast cancer?World journal of surgical oncology · 2021Article
- The influence on survival of delay in the treatment initiation of screening detected non-symptomatic breast cancer.Scientific reports · 2019Article
- Bioimpedance spectroscopy can precisely discriminate human breast carcinoma from benign tumors.Medicine · 2017Article
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Authors and funding
15 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntraoperative frozen section examination (IFSE) during breast cancer surgery can partly reflect the status of surgical treatment since the surgical method used directly determines the purpose of IFSE use in disease management. This study aims to investigate the application of, changing trends in, and factors influencing IFSE in the management of female breast cancer in China.
methodsWe collected the sociodemographic and clinical data of 4,211 breast cancer patients between 1999 and 2008 and statistically analyzed these data using χ2 or Fisher's exact tests.
resultsA total of 2,283 (54.22%) patients with breast cancer underwent IFSE. During the 10-year study period, IFSE use was associated with an increase in the number of sentinel lymph node biopsies (SLNB) and breast-conserving surgeries (BS) performed, with significant regional differences noted in this trend (P < 0.05). Patients' education, occupation, age, tumor size estimated by preoperative palpation, and the use of imaging examinations affected the purpose of IFSE use (P < 0.05).
conclusionsOur results show that the purpose of IFSE in the surgical treatment of breast cancer in China is gradually approaching that in developed countries. We believe that policymakers must address the differences in breast cancer treatment based on the socioeconomic status of patients. Lastly, the use of IFSE for determining tumor characteristics should be avoided as far as possible, and patient education and breast cancer screening programs tailored to the Chinese population should be established. Our findings may guide the formulation of breast cancer control strategies in China and other low-income countries.
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