Trial reportPsychopharmacology2015
Serotonin and dopamine differentially affect appetitive and aversive general Pavlovian-to-instrumental transfer.
Trial report in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Differential Associations of Dopamine and Serotonin With Reward and Punishment Processes in Humans: A Systematic Review and Meta-Analysis.JAMA psychiatry · 2025Pooled it
- Trial
- Activation of D1 receptors affects human reactivity and flexibility to valued cues.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Reward and avoidance learning in the context of aversive environments and possible implications for depressive symptoms.Psychopharmacology · 2019Trial
- Dopamine D2/3- and μ-opioid receptor antagonists reduce cue-induced responding and reward impulsivity in humans.Translational psychiatry · 2016Trial
- In search of the behavioral effects of fear: A paradigm to assess conditioned suppression in humans.Psychophysiology · 2022Article
- Neuromodulation of prefrontal cortex cognitive function in primates: the powerful roles of monoamines and acetylcholine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Amygdala response predicts clinical symptom reduction in patients with borderline personality disorder: A pilot fMRI study.Frontiers in behavioral neuroscience · 2022Article
- The Role of Tryptophan and Tyrosine in Executive Function and Reward Processing.International journal of tryptophan research : IJTR · 2020Review
- An Adaptation of Pavlovian-to-Instrumental Transfer (PIT) Methodology to Examine the Energizing Effects of Reward-Predicting Cues on Behavior in Young Adults.Frontiers in psychology · 2020Article
- Sign-tracking behavior is difficult to extinguish and resistant to multiple cognitive enhancers.Neurobiology of learning and memory · 2019Article
- Depression is associated with enhanced aversive Pavlovian control over instrumental behaviour.Scientific reports · 2018Article
- Drive in Sports: How Mental Fatigue Affects Endurance Performance.Frontiers in psychology · 2018Article
- Toward a multiscale modeling framework for understanding serotonergic function.Journal of psychopharmacology (Oxford, England) · 2017Review
- Catecholaminergic challenge uncovers distinct Pavlovian and instrumental mechanisms of motivated (in)action.eLife · 2017Article
- Modulation of cue-triggered reward seeking by cholinergic signaling in the dorsomedial striatum.The European journal of neuroscience · 2017Article
- Peripheral Serotonin 1B Receptor Transcription Predicts the Effect of Acute Tryptophan Depletion on Risky Decision-Making.The international journal of neuropsychopharmacology · 2017Article
- Interaction of Instrumental and Goal-Directed Learning Modulates Prediction Error Representations in the Ventral Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Congruence of Inherent and Acquired Values Facilitates Reward-Based Decision-Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- The Role of Serotonin (5-HT) in Behavioral Control: Findings from Animal Research and Clinical Implications.The international journal of neuropsychopharmacology · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleHuman motivation and decision-making is influenced by the interaction of Pavlovian and instrumental systems. The neurotransmitters dopamine and serotonin have been suggested to play a major role in motivation and decision-making, but how they affect this interaction in humans is largely unknown.
objectiveWe investigated the effect of these neurotransmitters in a general Pavlovian-to-instrumental transfer (PIT) task which measured the nonspecific effect of appetitive and aversive Pavlovian cues on instrumental responses.
methodsFor that purpose, we used selective dietary depletion of the amino acid precursors of serotonin and dopamine: tryptophan (n = 34) and tyrosine/phenylalanine (n = 35), respectively, and compared the performance of these groups to a control group (n = 34) receiving a nondepleted (balanced) amino acid drink.
resultsWe found that PIT differed between groups: Relative to the control group that exhibited only appetitive PIT, we found reduced appetitive PIT in the tyrosine/phenylalanine-depleted group and enhanced aversive PIT in the tryptophan-depleted group.
conclusionsThese results demonstrate a differential involvement of serotonin and dopamine in motivated behavior. They suggest that reductions in serotonin enhance the motivational influence of aversive stimuli on instrumental behavior and do not affect the influence of appetitive stimuli, while reductions in dopamine diminish the influence of appetitive stimuli. No conclusions could be drawn about how dopamine affects the influence of aversive stimuli. The interplay of both neurotransmitter systems allows for flexible and adaptive responses depending on the behavioral context.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.