Observational studyEndocrine2015
Post-thyroidectomy chronic asthenia: self-deception or disease?
Observational study in Endocrine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- 2025 American Thyroid Association Management Guidelines for Adult Patients with Differentiated Thyroid Cancer.Thyroid : official journal of the American Thyroid Association · 2025Guideline
- Pre-surgery dietician counseling can prevent post-thyroidectomy body weight gain: results of an intervention trial.Endocrine · 2023Trial
- Thyroidectomy, especially total thyroidectomy, adversely affects erectile function in men.BMC endocrine disorders · 2025Article
- Thyroidectomy Effects on the Body Mass Index and Thyroid-Stimulating Hormone: A Systematic Review and Meta-Analysis.Cureus · 2024Review
- Weight Gain and Asthenia Following Thyroidectomy: Current Knowledge from Literature Review.Journal of clinical medicine · 2022Review
- Article
- Thyroid Lobectomy for Low-Risk Papillary Thyroid Cancer: A National Survey of Low- and High-Volume Surgeons.Annals of surgical oncology · 2021Article
- Patients' Reaction to Diagnosis with Thyroid Cancer or an Indeterminate Thyroid Nodule.Thyroid : official journal of the American Thyroid Association · 2021Article
- Hemithyroidectomy for Thyroid Cancer: A Review.Medicina (Kaunas, Lithuania) · 2020Review
- Surgical Treatment in Papillary Thyroid Microcarcinoma.Sisli Etfal Hastanesi tip bulteni · 2018Review
- The prevalence of post-thyroidectomy chronic asthenia: a prospective cohort study.Langenbeck's archives of surgery · 2017Article
- Papillary thyroid microcarcinoma: decision-making, extent of surgery, and outcomes.The Journal of surgical research · 2017Article
- Long-term esophageal motility changes after thyroidectomy: associations with aerodigestive disorders.Il Giornale di chirurgiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is clinical evidence that post-total thyroidectomy (TT) patients can present persistent asthenia. The aim of this study was to evaluate the prevalence of asthenia symptoms in such patients, assess whether a chronic asthenia syndrome could be caused by TT or become evident after it. An observational study was carried out comparing two groups of 100 patients each, all with homogeneous characteristics. Group A was treated with total lobectomy (TL), Group B with TT. All patients presented normal thyroid hormone levels. The patients were interviewed in order to identify the ones affected by post-operative asthenia persisting for at least six months, with reduced ability to perform physical and mental work, not showing improvement with rest. The severity of the symptoms has been measured by means of the brief fatigue inventory (BFI). Statistical analysis was performed to evaluate statistically significative differences between groups and prognostic factors in TT group. The incidence of post-operative asthenia was 0 % after TL and 25 % after TT, with the operation being the only significant variable. Asthenia is well known as symptom of post-thyroidectomy, but it has not been adequately investigated as consequence of surgery. We demonstrated that the complete removal of the thyroid gland could determine chronic post-thyroidectomy asthenia, although with intensity limited to low/moderate. Post-thyroidectomy asthenia is a relevant sequela interfering with quality of life of at least 25 % of patients operated, suggesting the need to identify its real causes and limit the indication to TT only when strictly required.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.