ArticleJournal of affective disorders2014
Altered brain network modules induce helplessness in major depressive disorder.
Article in Journal of affective disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Impulsivity and non-suicidal self-injury in adolescents: a systematic review and meta-analysis of longitudinal studies.Frontiers in psychiatry · 2025Pooled it
- Psychoradiological patterns of small-world properties and a systematic review of connectome studies of patients with 6 major psychiatric disordersJournal of psychiatry & neuroscience : JPN · 2018Pooled it
- Alterations of White Matter Structural Brain Network in Children With Sensorineural Hearing Loss: A Graph Theory Analysis for Auditory Sensitivity Period.Neural plasticity · 2026Article
- Spatial entropy of brain network landscapes: a novel method to assess spatial disorder in brain networks.bioRxiv : the preprint server for biology · 2025Article
- Brain functional connectivity changes in amyotrophic lateral sclerosis with apathy and depression.Journal of neurology · 2025Article
- Long-term risk of late-life depression in widowed elderly: a five-year follow-up study.BMC geriatrics · 2025Article
- Over-integration of visual network in major depressive disorder and its association with gene expression profiles.Translational psychiatry · 2025Article
- Abnormalities in rich-club connections are associated with an exacerbation of genetic susceptibility to schizophrenia.BMC psychiatry · 2024Article
- Community detection in the human connectome: Method types, differences and their impact on inference.Human brain mapping · 2024Article
- Classification accuracy of structural and functional connectomes across different depressive phenotypes.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Article
- Prefrontal cortex and depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Effects of escitalopram therapy on resting-state functional connectivity of subsystems of the default mode network in unmedicated patients with major depressive disorder.Translational psychiatry · 2021Article
- Disrupted intrinsic functional brain topology in patients with major depressive disorder.Molecular psychiatry · 2021Article
- The Moderating Effects of Emotions on the Relationship Between Self-Reported Individual Traits and Actual Risky Driving Behaviors.Psychology research and behavior management · 2021Article
- Different Modular Organization Between Early Onset and Late Onset Depression: A Study Base on Granger Causality Analysis.Frontiers in aging neuroscience · 2021Article
- Altered Functional Connectivity Within and Between Salience and Sensorimotor Networks in Patients With Functional Constipation.Frontiers in neuroscience · 2021Article
- Brain Plasticity Reflects Specialized Cognitive Development Induced by Musical Training.Cerebral cortex communications · 2021Article
- Differences in Driving Intention Transitions Caused by Driver's Emotion Evolutions.International journal of environmental research and public health · 2020Article
- Disrupted Structural Brain Network Organization Behind Depressive Symptoms in Major Depressive Disorder.Frontiers in psychiatry · 2020Article
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Authors and funding
11 authors.
Funding
Abstract
objectiveThe abnormal brain functional connectivity (FC) has been assumed to be a pathophysiological aspect of major depressive disorder (MDD). However, it is poorly understood, regarding the underlying patterns of global FC network and their relationships with the clinical characteristics of MDD.
methodsResting-state functional magnetic resonance imaging data were acquired from 16 first episode, medication-naïve MDD patients and 16 healthy control subjects. The global FC network was constructed using 90 brain regions. The global topological patterns, e.g., small-worldness and modularity, and their relationships with depressive characteristics were investigated. Furthermore, the participant coefficient and module degree of MDD patients were measured to reflect the regional roles in module network, and the impairment of FC was examined by network based statistic.
resultsSmall-world property was not altered in MDD. However, MDD patients exhibited 5 atypically reorganized modules compared to the controls. A positive relationship was also found among MDD patients between the intra-module I and helplessness factor evaluated via the Hamilton Depression Scale. Specifically, eight regions exhibited the abnormal participant coefficient or module degree, e.g., left superior orbital frontal cortex and right amygdala. The decreased FC was identified among the sub-network of 24 brain regions, e.g., frontal cortex, supplementary motor area, amygdala, thalamus, and hippocampus. LIMITATION: The limited size of MDD samples precluded meaningful study of distinct clinical characteristics in relation to aberrant FC.
conclusionsThe results revealed altered patterns of brain module network at the global level in MDD patients, which might contribute to the feelings of helplessness.
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