ArticlePloS one2014
Sensitization to food and inhalant allergens in relation to atopic diseases in early childhood: a birth cohort study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 4 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 4 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Towards Sensitization Profiling for Allergy Prevention in Russia: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Rational Allergy Practice Guidelines by the Indian Academy of Pediatrics (IAP) and IAP-Allergy and Applied Immunology Chapter.Indian pediatrics · 2026Guideline
- Probiotics in infants for prevention of allergic disease.The Cochrane database of systematic reviews · 2025Pooled it
- Machine learning-derived asthma and allergy trajectories in children: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Cat and dog ownership during/after the first year of life and risk for sensitization and reported allergy symptoms at age 13.Immunity, inflammation and disease · 2019Trial
- Maternal allergen-specific IgG might protect the child against allergic sensitization.The Journal of allergy and clinical immunology · 2019Trial
- A longitudinalScientific data · 2026Article
- Characterising the allergen landscape in paediatric allergic rhinitis and/or asthma.BMJ open respiratory research · 2026Article
- Prevalence and risk factors ofThe World Allergy Organization journal · 2025Article
- Prevalence of Allergen-Specific IgE Positivity and Serum Immunoglobulin E Concentrations of Allergens in Dogs with Suspected Allergic Dermatitis Using the Multiple Allergen Simultaneous Test in South Korea.Veterinary sciences · 2025Article
- Sensitization to inhaled and food allergen sources in patients with allergic diseases in Eastern China.Frontiers in allergy · 2025Article
- Multi-biofluid metabolomics analysis of allergic respiratory rhinitis and asthma in early childhood.The World Allergy Organization journal · 2025Article
- Prenatal Factors in the Development of Allergic Diseases.International journal of molecular sciences · 2024Review
- Vitamin D level is inversely related to allergen sensitization for risking atopic dermatitis in early childhood.The World Allergy Organization journal · 2024Article
- Early childhood atopic phenotypes and the development of allergic respiratory disease.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2023Article
- Food hypersensitivity: an examination of factors influencing symptoms and temporal changes in the prevalence of sensitization in an adult sample.European journal of clinical nutrition · 2023Article
- Basophils Predict Mite Sensitization in Patients with Kawasaki Disease.Children (Basel, Switzerland) · 2023Article
- Longitudinal analysis of the impact of smoking exposure on atopic indices and allergies in early childhood.The World Allergy Organization journal · 2023Article
- Review
- Maternal prenatal psychological distress associates with offspring early-life wheezing - FinnBrain Birth Cohort.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesA correct interpretation of sensitization to common allergens is critical in determining susceptibility to allergic diseases. The aim of this study was to investigate the patterns of sensitization to food and inhalant allergens, and their relation to the development of atopic diseases in early childhood.
methodsChildren aged 0 through 4 years from a birth cohort in the Prediction of Allergies in Taiwanese Children (PATCH) study were enrolled. Specific IgE antibody against food and inhalant allergens were measured and their association between total serum IgE levels and atopic diseases were assessed.
resultsA total of 182 children were regular followed up at clinics for a four-year follow-up period. The prevalence of food allergen sensitization increased markedly after 6 months of age, reaching up to 47% at 1.5 years of age and then declined significantly to 10% in parallel with a considerable increase in the prevalence of sensitization to inhalant allergens up to 25% at age 4. Food allergen sensitization appeared to be mainly associated with the elevation of serum total IgE levels before age 2. A combined sensitization to food and inhalant allergens had an additive effect on serum IgE levels after age 2, and was significantly associated with the risk of developing atopic diseases at age 4.
conclusionsSensitization to food occurs early in life, in parallel with the rising prevalence of sensitization to inhalant allergens at older age. A combined sensitization to food and inhalant allergens not only has an additive increase in serum IgE antibody production but also increases the risk of developing allergic respiratory diseases in early childhood.
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