Evidence map›Paper›PMID 25033432›Full record

ArticleColloids and surfaces. B, Biointerfaces2014

Novel anti-infective activities of chitosan immobilized titanium surface with enhanced osteogenic properties.

Niranjan Ghimire, Jie Luo, Ruogu Tang, Yuyu Sun, Ying Deng

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Colloids and surfaces. B, Biointerfaces, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Surface Modification of Bacterial Cellulose for Biomedical Applications.International journal of molecular sciences · 2022
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Niranjan GhimireDepartment of Biomedical Engineering, University of South Dakota, 4800 North Career Avenue, Sioux Falls, SD 57107, USA.
Jie LuoDepartment of Chemistry, The University of Massachusetts, One University Avenue, Lowell, MA 01854, USA.
Ruogu TangDepartment of Chemistry, The University of Massachusetts, One University Avenue, Lowell, MA 01854, USA.
Yuyu SunDepartment of Chemistry, The University of Massachusetts, One University Avenue, Lowell, MA 01854, USA. Electronic address: yuyu_sun@uml.edu.
Ying DengDepartment of Biomedical Engineering, University of South Dakota, 4800 North Career Avenue, Sioux Falls, SD 57107, USA. Electronic address: Ying.Deng@usd.edu.
University of Massachusetts Lowell · USUniversity of South Dakota · US

Funding

Orthopedic implant materials with bacteria-resistant and osteogenic functionsR21AR065625 · NIAMS · UNIVERSITY OF MASSACHUSETTS LOWELL · PI DENG, YING, SUN, YUYU · 2013 to 2014
$357k
NIAMS NIH HHS R21 AR065625NIAMS NIH HHS R21AR065625
6 · The paper itself

Abstract

We have covalently immobilized chitosan onto a titanium (Ti) surface to manage implant-related infection and poor osseointegration, two of the major complications of orthopedic implants. The Ti surface was first treated with sulfuric acid (SA) and then covalently grafted with chitosan. Surface roughness, contact angle and surface zeta potential of the samples were markedly increased by the sulfuric acid treatment and the subsequent chitosan immobilization. The chitosan-immobilized Ti (SA-CS-Ti) showed two novel antimicrobial roles: it (a) prevented the invasion and internalization of bacteria into the osteoblast-like cells, and (b) significantly increased the susceptibility of adherent bacteria to antibiotics. In addition, the sulfuric acid-treated Ti (SA-Ti) and SA-CS-Ti led to significantly increased (P<0.05) osteoblast-like cell attachment, enhanced cell proliferation, and better osteogenic differentiation and mineralization of osteoblast-like cells.

Indexed as

Alkaline PhosphataseAnti-Infective AgentsCell AdhesionCell LineCell ProliferationChitosanHumansOsteoblastsOsteogenesisSurface PropertiesTitaniumAlkaline PhosphataseAnti-Infective AgentsChitosanTitaniumAntibiotic-susceptibilityChitosan immobilizationInternalizationInvasionOsteogenic differentiation

Identifiers

PMID25033432
PMCPMC4172512
OpenAlexW2027075488

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.