ArticleNeuron2014
Pyramidal cell-interneuron interactions underlie hippocampal ripple oscillations.
Article in Neuron, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 287 papers.
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Who cites it
287 citing papers in PubMed.
- Cross-region neuron co-firing mediated by ripple oscillations supports distributed working memory representations.Nature neuroscience · 2026Article
- Physiological landmarks reveal the laminar organization of the primate hippocampus.bioRxiv : the preprint server for biology · 2026Article
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- Sublayer- and pathway-specific control of CA1 input processing by VIP interneurons.The Journal of physiology · 2026Article
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- High-frequency visual stimulation can increase medial temporal lobe ripple oscillation density.Communications medicine · 2026Article
- Anti-NMDAR encephalitis impairs intrinsic hippocampal dynamics through neuronal hypercoupling, hub dominance, and aberrant ensembles.Molecular psychiatry · 2026Article
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- A Conserved Mammalian Hippocampal Navigation Motif Reconfigured for Primate Vision.bioRxiv : the preprint server for biology · 2026Article
- Article
- Dendritic Inhibition Terminates Plateau Potentials in CA1 Pyramidal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Homeostatic preservation of action potential waveform by Notch and Nerfin-1.Current biology : CB · 2026Article
- vCA1 SST neurons represent avoidance states that guide anxiety-related behavioral choices.bioRxiv : the preprint server for biology · 2026Article
- Implication of the thalamus in sleep alterations observed in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Sensory encoding and memory retrieval are coordinated with propagating waves in the human brain.Nature communications · 2026Article
- Dysfunction of GABAergic interneurons underlies altered neural network oscillations associated with epileptiform activity in PPT1-deficient mice.Translational psychiatry · 2026Article
- Hippocampal synchrony dynamically gates cortical connectivity across brain states.Scientific reports · 2026Article
- Bridging Model and Experiment in Systems Neuroscience with Cleo: The Closed-Loop, Electrophysiology, and Optophysiology Simulation Testbed.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- A State-Space Framework for Causal Detection of Hippocampal Ripple-Replay Events.IEEE transactions on bio-medical engineering · 2026Article
- Tuning excitatory input to fast-spiking parvalbumin-positive interneurons: a lever for plasticity and hyperexcitability across the lifespan.Frontiers in synaptic neuroscience · 2026Article
227 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
High-frequency ripple oscillations, observed most prominently in the hippocampal CA1 pyramidal layer, are associated with memory consolidation. The cellular and network mechanisms underlying the generation, frequency control, and spatial coherence of the rhythm are poorly understood. Using multisite optogenetic manipulations in freely behaving rodents, we found that depolarization of a small group of nearby pyramidal cells was sufficient to induce high-frequency oscillations, whereas closed-loop silencing of pyramidal cells or activation of parvalbumin- (PV) or somatostatin-immunoreactive interneurons aborted spontaneously occurring ripples. Focal pharmacological blockade of GABAA receptors abolished ripples. Localized PV interneuron activation paced ensemble spiking, and simultaneous induction of high-frequency oscillations at multiple locations resulted in a temporally coherent pattern mediated by phase-locked interneuron spiking. These results constrain competing models of ripple generation and indicate that temporally precise local interactions between excitatory and inhibitory neurons support ripple generation in the intact hippocampus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.