Evidence map›Paper›PMID 25033174›Full record

ArticleNeuron2014

Slow neuromodulation mediated by ATP P2X receptors.

Ji Xu, Baljit S Khakh

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Short- and long-term (trophic) purinergic signalling.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ji XuDepartment of Physiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Baljit S KhakhDepartment of Physiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address: bkhakh@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

Functions of astrocyte calcium signaling in the striatumR01NS060677 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KHAKH, BALJIT · 2008 to 2018
$4.3M
Optical reporter mice to study P2X4 receptors in microgliaR21NS073980 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KHAKH, BALJIT · 2011 to 2012
$385k
NINDS NIH HHS R01 NS060677NINDS NIH HHS R21 NS073980
6 · The paper itself

Abstract

ATP-gated P2X receptors are widely expressed in the nervous system, but their physiological roles are not fully understood. New insights from Pougnet et al. (2014) in this issue of Neuron show that postsynaptic P2X receptors may be activated by ATP released from astrocytes and function to downregulate synaptic AMPA receptors in hippocampal neurons.

Indexed as

Adenosine TriphosphateAnimalsHippocampusNeuronsReceptors, AMPAReceptors, Purinergic P2XSynapsesAdenosine TriphosphateReceptors, AMPAReceptors, Purinergic P2X

Identifiers

PMID25033174
PMCPMC4171101
OpenAlexW2063505659

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.