Evidence map›Paper›PMID 25033061›Full record

ReviewAnnual review of nutrition2014

Sulfur as a signaling nutrient through hydrogen sulfide.

Omer Kabil, Victor Vitvitsky, Ruma Banerjee

Open access · greenAbstract readReview
In one paragraph

Review in Annual review of nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 123 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Gut sulfide metabolism modulates behavior and brain bioenergetics.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Review
  7. Review
  8. Signaling Paradigms of HAntioxidants (Basel, Switzerland) · 2024
    Review
  9. Article
  10. Ironing out the details: ferroptosis and its relevance to diabetic cardiomyopathy.American journal of physiology. Regulatory, integrative and comparative physiology · 2023
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. HBiomedicines · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. HInternational journal of molecular sciences · 2022
    Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Omer KabilDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0600; email: rbanerje@umich.edu.
Victor Vitvitsky
Ruma Banerjee
University of Michigan–Ann Arbor · US

Funding

Transsulfuration and HyperhomocysteinemiaR01HL058984 · NHLBI · UNIVERSITY OF NEBRASKA LINCOLN · PI BANERJEE, RUMA V · 1997 to 2020
$6.0M
NHLBI NIH HHS HL58984NHLBI NIH HHS R01 HL058984
6 · The paper itself

Abstract

Hydrogen sulfide (H₂S) has emerged as an important signaling molecule with beneficial effects on various cellular processes affecting, for example, cardiovascular and neurological functions. The physiological importance of H₂S is motivating efforts to develop strategies for modulating its levels. However, advancement in the field of H₂S-based therapeutics is hampered by fundamental gaps in our knowledge of how H₂S is regulated, its mechanism of action, and its molecular targets. This review provides an overview of sulfur metabolism; describes recent progress that has shed light on the mechanism of H₂S as a signaling molecule; and examines nutritional regulation of sulfur metabolism, which pertains to health and disease.

Indexed as

DietModels, BiologicalSignal TransductionAgingAmino Acids, SulfurAnimalsCardiovascular SystemCentral Nervous SystemEndoplasmic Reticulum StressEndothelium, VascularHumansHydrogen SulfideNutritional RequirementsSulfurSulfur CompoundsAmino Acids, SulfurHydrogen SulfideSulfurSulfur Compoundshydrogen sulfidenutritionsignalingsulfide oxidationsulfur metabolism

Identifiers

PMID25033061
PMCPMC4684266
OpenAlexW2121003339

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.