ReviewPLoS neglected tropical diseases2014
Oroya fever and verruga peruana: bartonelloses unique to South America.
Review in PLoS neglected tropical diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 107 citations in OpenAlex.
- Drug target mining and in silico screening of Tibetan plant metabolites for potential alleviation of Oroya fever, a neglected tropical disease.Scientific reports · 2026Article
- Molecular identification of Bartonella henselae in dogs with clinical suspicion of visceral leishmaniasis.Revista do Instituto de Medicina Tropical de Sao Paulo · 2026Article
- Porin A and α/β-hydrolase are necessary and sufficient for hemolysis induced by Bartonella bacilliformis.Nature communications · 2025Article
- Updating the distribution of sand flies in Hungary with implications on their biology and ecology.Current research in parasitology & vector-borne diseases · 2025Article
- Genetic diversity of Bartonella species in small mammals in the Qinghai Menyuan section of Qilian Mountain National Park, China.Scientific reports · 2024Article
- Bartonella spp. in Phlebotominae Sand Flies, Brazil.Emerging infectious diseases · 2024Article
- Vector-Borne Zoonotic Lymphadenitis-The Causative Agents, Epidemiology, Diagnostic Approach, and Therapeutic Possibilities-An Overview.Life (Basel, Switzerland) · 2024Review
- Baculovirus-Assisted Production ofPathogens (Basel, Switzerland) · 2024Article
- Mapping the distribution of sandflies and sandfly-associated pathogens in China.PLoS neglected tropical diseases · 2024Article
- Single-nucleotide polymorphisms in ialB, gltA and rpoB genes of Bartonella bacilliformis isolated from patients in endemic Peruvian regions.PLoS neglected tropical diseases · 2023Article
- Experimental Colonization of Sand Flies (Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2023Article
- Advancements in understanding the molecular and immune mechanisms ofFrontiers in microbiology · 2023Review
- Identification of theProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Prevalence and diversity of small rodent-associated Bartonella species in Shangdang Basin, China.PLoS neglected tropical diseases · 2022Article
- Detection and genetic diversity of Bartonella species in small mammals from the central region of the Qinghai-Tibetan Plateau, China.Scientific reports · 2022Article
- Article
- Sand flies: Basic information on the vectors of leishmaniasis and their interactions with Leishmania parasites.Communications biology · 2022Review
- Molecular detection and genetic characterization of small rodents associated Bartonella species in Zhongtiao Mountain, China.PloS one · 2022Article
- The Continuing Ophthalmic Challenge ofOphthalmology science · 2021Article
- Comparison of sand fly trapping approaches for vector surveillance of Leishmania and Bartonella species in ecologically distinct, endemic regions of Peru.PLoS neglected tropical diseases · 2021Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Bartonella bacilliformis is the bacterial agent of Carrión's disease and is presumed to be transmitted between humans by phlebotomine sand flies. Carrión's disease is endemic to high-altitude valleys of the South American Andes, and the first reported outbreak (1871) resulted in over 4,000 casualties. Since then, numerous outbreaks have been documented in endemic regions, and over the last two decades, outbreaks have occurred at atypical elevations, strongly suggesting that the area of endemicity is expanding. Approximately 1.7 million South Americans are estimated to be at risk in an area covering roughly 145,000 km2 of Ecuador, Colombia, and Peru. Although disease manifestations vary, two disparate syndromes can occur independently or sequentially. The first, Oroya fever, occurs approximately 60 days following the bite of an infected sand fly, in which infection of nearly all erythrocytes results in an acute hemolytic anemia with attendant symptoms of fever, jaundice, and myalgia. This phase of Carrión's disease often includes secondary infections and is fatal in up to 88% of patients without antimicrobial intervention. The second syndrome, referred to as verruga peruana, describes the endothelial cell-derived, blood-filled tumors that develop on the surface of the skin. Verrugae are rarely fatal, but can bleed and scar the patient. Moreover, these persistently infected humans provide a reservoir for infecting sand flies and thus maintaining B. bacilliformis in nature. Here, we discuss the current state of knowledge regarding this life-threatening, neglected bacterial pathogen and review its host-cell parasitism, molecular pathogenesis, phylogeny, sand fly vectors, diagnostics, and prospects for control.
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