ArticleCell death & disease2014
The transient expression of miR-203 and its inhibiting effects on skeletal muscle cell proliferation and differentiation.
Article in Cell death & disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 104 citations in OpenAlex.
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- From Correlation to Causation: Defining Gene and RNA Function in Poultry Muscle Biology Using In Vivo Genetic Tools.Biomolecules · 2025Review
- Silencing epileptic storms: targeting miRNA-lncRNA crosstalk in astrocytes and microglia to disarm neuroinflammatory triggers.Frontiers in molecular neuroscience · 2025Review
- Signaling pathways and regulatory networks in quail skeletal muscle development: insights from whole transcriptome sequencing.Poultry science · 2024Article
- Bulk and single-cell alternative splicing analyses reveal roles of TRA2B in myogenic differentiation.Cell proliferation · 2024Article
- MicroRNA-142a-3p regulates neurogenic skeletal muscle atrophy by targeting Mef2a.Molecular therapy. Nucleic acids · 2023Article
- Local GHR roles in regulation of mitochondrial function through mitochondrial biogenesis during myoblast differentiation.Cell communication and signaling : CCS · 2023Article
- Timing Expression of miR203a-3p during OA Disease: Preliminary In Vitro Evidence.International journal of molecular sciences · 2023Article
- Transcriptome RNA Sequencing Reveals That Circular RNAs Are Abundantly Expressed in Embryonic Breast Muscle of Duck.Veterinary sciences · 2023Article
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- Regulation of Non-Coding RNA in the Growth and Development of Skeletal Muscle in Domestic Chickens.Genes · 2022Review
- Mining of chicken muscle growth genes and the function of important candidate geneFrontiers in physiology · 2022Article
- TMEM182 interacts with integrin beta 1 and regulates myoblast differentiation and muscle regeneration.Journal of cachexia, sarcopenia and muscle · 2021Article
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- Key Genes Regulating Skeletal Muscle Development and Growth in Farm Animals.Animals : an open access journal from MDPI · 2021Review
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- Functional Non-coding RNA During Embryonic Myogenesis and Postnatal Muscle Development and Disease.Frontiers in cell and developmental biology · 2021Review
- The emerging roles of circular RNAs in regulating the fate of stem cells.Molecular and cellular biochemistry · 2021Review
2 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have shown that miR-203 is a skin-specific microRNA (miRNA) with a profound role in skin cell differentiation. However, emerging microarray and deep sequencing data revealed that miR-203 is also expressed in embryonic skeletal muscle and myoblasts. In this study, we found that miR-203 was transiently upregulated in chicken embryos on days 10 to 16 (E10-E16) and was sharply downregulated and even not expressed after E16 in chicken embryonic skeletal muscle. Histological profiles and weight variations of embryo skeletal muscle revealed that miR-203 expression is correlated with muscle development. In vitro experiments showed that miR-203 exhibited downregulated expression during myoblast differentiation into myotubes. miR-203 overexpression inhibited myoblast proliferation and differentiation, whereas its loss-of-function increased myoblast proliferation and differentiation. During myogenesis, miR-203 can target and inhibit the expression of c-JUN and MEF2C, which were important for cell proliferation and muscle development, respectively. The overexpression of c-JUN significantly promoted myoblast proliferation. Conversely, knockdown of c-JUN by siRNA suppressed myoblast proliferation. In addition, the knockdown of MEF2C by siRNA significantly inhibited myoblast differentiation. Altogether, these data not only suggested that the expression of miR-203 is transitory during chicken skeletal muscle development but also showed a novel role of miR-203 in inhibiting skeletal muscle cell proliferation and differentiation by repressing c-JUN and MEF2C, respectively.
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