ReviewAnnual review of neuroscience2014
Neural tube defects.
Review in Annual review of neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 315 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
315 citing papers in PubMed, 9 syntheses or guidelines pooled it, 628 citations in OpenAlex.
- The effectiveness of mandatory folic acid fortification compared with pre-fortification periods on reducing neural tube defects (NTDs): a systematic review and meta-analysis.BMC nutrition · 2026Pooled it
- Consumption of folic acid fortified foods among Hispanic women of reproductive age in the US: a systematic review.BMC public health · 2025Pooled it
- Folic acid supplementation during preconception period in sub-Saharan African countries: A systematic review and meta-analysis.PloS one · 2025Pooled it
- Evaluating the potential role of determinants of health on encephalocele patient outcomes - a combined retrospective study and systematic review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Pooled it
- Birth prevalence and risk factors of neural tube defects in Ethiopia: a systematic review and meta-analysis.BMJ open · 2023Pooled it
- Prenatal Exposure to Toxic Metals and Neural Tube Defects: A Systematic Review of the Epidemiologic Evidence.Environmental health perspectives · 2023Pooled it
- Provision of folic acid for reducing arsenic toxicity in arsenic-exposed children and adults.The Cochrane database of systematic reviews · 2021Pooled it
- Preclinical stem cell therapy in fetuses with myelomeningocele: A systematic review and meta-analysis.Prenatal diagnosis · 2021Pooled it
- Cranial findings detected by second-trimester ultrasound in fetuses with myelomeningocele: a systematic review.BJOG : an international journal of obstetrics and gynaecology · 2021Pooled it
- Prenatal Cerium Exposure and Neural Tube Defect Risk: A Case-control Study in Shanxi, China.Biological trace element research · 2026Article
- Congenital Anomaly Prevalence: A 10-Year Retrospective Study in a Tertiary Hospital in Turkey.Birth defects research · 2026Article
- Whole exome sequencing uncovers novel genetic insights into Tethered cord syndrome.Molecular genetics and genomics : MGG · 2026Article
- Effects of Nimodipine on Neural Tube Development in Early Chick Embryos.Birth defects research · 2026Article
- Association of zygosity and chorionicity with anatomical distribution of congenital malformations in twin pregnancies.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026Article
- Myelomeningocele in Slovenia: An 18-Year National Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- Association of premarital medical check-ups and folic acid knowledge, attitudes, and practices with the occurrence of neural tube defects in Guangxi, China (2009-2023).Journal of global health · 2026Article
- The primary cilium at the helm: gatekeeper of TGF-β superfamily signaling in development, homeostasis, and disease.Biochemical Society transactions · 2026Review
- Quantitative Analysis of Cell and Tissue Shape During Mouse Cranial Neural Tube Closure.Bio-protocol · 2026Article
- Dietary folate education versus once-weekly iron folic acid supplementation for improving folate status in reproductive-aged women: a quasi-experimental study.BMC nutrition · 2026Article
- Quantitative live imaging reveals PRICKLE1 controls junctional neural tube morphogenesis independent of Planar Cell Polarity.Nature communications · 2026Article
255 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Neural tube defects (NTDs), including spina bifida and anencephaly, are severe birth defects of the central nervous system that originate during embryonic development when the neural tube fails to close completely. Human NTDs are multifactorial, with contributions from both genetic and environmental factors. The genetic basis is not yet well understood, but several nongenetic risk factors have been identified as have possibilities for prevention by maternal folic acid supplementation. Mechanisms underlying neural tube closure and NTDs may be informed by experimental models, which have revealed numerous genes whose abnormal function causes NTDs and have provided details of critical cellular and morphological events whose regulation is essential for closure. Such models also provide an opportunity to investigate potential risk factors and to develop novel preventive therapies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.