ArticleIranian Red Crescent medical journal2014
Hydro-methanolic extract of cornus MAS L. And blood glucose, lipid profile and hematological parameters of male rats.
Article in Iranian Red Crescent medical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
- Effect of Leaf Extracts of Cornus sanguinea L., C. sericea L., and C. alba L. on Digestive Enzymes and Blood Coagulation In Vitro.Plant foods for human nutrition (Dordrecht, Netherlands) · 2026Article
- Health-Promoting Properties of Anthocyanins from Cornelian Cherry (Molecules (Basel, Switzerland) · 2024Review
- An Overview of Traditional Uses, Phytochemical Compositions and Biological Activities of Edible Fruits of European and AsianFoods (Basel, Switzerland) · 2022Review
- Current update on herbal sources of antithrombotic activity-a comprehensive review.The Egyptian journal of internal medicine · 2022Review
- A systematic review and meta-analysis of the impact of cornelian cherry consumption on blood lipid profiles.Food science & nutrition · 2021Review
- Middle East Medicinal Plants in the Treatment of Diabetes: A Review.Molecules (Basel, Switzerland) · 2021Review
- Effects ofIndian journal of clinical biochemistry : IJCB · 2020Article
- Effects of Cornelian Cherry on Atherosclerosis and Its Risk Factors.Oxidative medicine and cellular longevity · 2019Review
- Review
- Effects ofResearch in pharmaceutical sciences · 2017Article
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6 authors.
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Abstract
backgroundCornus mas L, an olive-shaped red-colored single-seeded fruit, is used in traditional medicine in different parts of Europe and Asia.
objectivesIn the present study, 40 male Wistar rats were randomly divided into five groups, and the effects of 21 days of intraperitoneally (IP) administration of 50, 200 and 400 mg/kg body weight of C. mas hydro-methanolic extract on the rats hematological and biochemical parameters were investigated. The experimental study was carried out in Tabriz, Iran. MATERIALS AND
methodsThe hematology and biochemical tests were performed by the Technicon H1 Hematology Analyzer and enzymatic methods, respectively.
resultsThe results indicated that all doses of the extract caused significant (P < 0.05) decreases in the hemoglobin distribution width (HDW) (2.3 ± 0.2 vs. 2.5 ± 0.2, P = 0.049) and platelet distribution width (PDW) (56.5 ± 1.8 vs. 63.9 ± 3.6, P = 0.001) of the treated groups vs. control group, whereas only high doses caused significant elevation in the mean corpuscular hemoglobin concentration (MCHC) (30.3 ± 0.8 vs. 28.6 ± 0.6, P = 0.047), mean platelet volume (MPV) (5.0 ± 0.6 vs. 4.1 ± 0.3, P = 0.002), total platelet mass (PCT) (0.33 ± 0.07 vs. 0.26 ± 0.01, P = 0.050), and significant decrease in the red cell distribution width (RDW) (13.8 ± 0.4 vs. 14.7 ± 1.3, P = 0.048) of the treated groups vs. control group.
conclusionsDecreasing effect of the extract on platelet activity might classify it as an alternative for antiplatelet therapy in cardiovascular diseases (CVD). The results of this study suggested that further investigations with higher doses of C. mas fruit extract are necessary to obtain significant protective and nonprotective changes in hematological and biochemical parameters.
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