Evidence map›Paper›PMID 25031754›Full record

ArticleInternational journal of clinical and experimental pathology2014

Phosphorylation status of Akt and caspase-9 in gastric and colorectal carcinomas.

Akiko Sangawa, Michiko Shintani, Naoki Yamao, Shingo Kamoshida

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Role of PI3K/Akt signaling pathway in cardiac fibrosis.Molecular and cellular biochemistry · 2021
    Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Targeting AKT for cancer therapy.Expert opinion on investigational drugs · 2019
    Review
  14. Article
  15. Article
  16. Proposed Molecular and miRNA Classification of Gastric Cancer.International journal of molecular sciences · 2018
    Review
  17. Article
  18. Article
  19. Caspase-3 and caspase-8 expression in breast cancer: caspase-3 is associated with survival.Apoptosis : an international journal on programmed cell death · 2017
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Akiko SangawaLaboratory of Pathology, Division of Medical Biophysics, Kobe University Graduate School of Health Sciences Kobe, Japan ; Department of Diagnostic Pathology, Osaka Red Cross Hospital Osaka, Japan.
Michiko ShintaniLaboratory of Pathology, Division of Medical Biophysics, Kobe University Graduate School of Health Sciences Kobe, Japan.
Naoki YamaoDepartment of Clinical Laboratory, Kuma Hospital Kobe, Japan.
Shingo KamoshidaLaboratory of Pathology, Division of Medical Biophysics, Kobe University Graduate School of Health Sciences Kobe, Japan.
Kobe University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The serine/threonine protein kinase B/Akt plays a central role in the coordination of multiple signal transduction processes involved in transcriptional regulation, cell survival, and apoptosis. Activation of Akt kinase is a prognostic factor in several types of cancers; however, its role in gastrointestinal cancers is not fully understood. Caspase-9 is an Akt substrate that belongs to the caspase family of proteases, which function as initiators of the mitochondrial apoptotic pathway. Little is known about the role of caspase-9 phosphorylation, which downregulates the apoptotic activity of the enzyme. In this study, we investigated the expression of phosphorylated (p)-Akt and phosphorylated (p)-caspase-9 in gastric and colorectal carcinoma and the relationship between p-Akt and p-caspase-9 expression and clinicopathological parameters of gastric and colorectal cancer patients. In total, 75 samples of advanced gastric adenocarcinoma (37 well-to-moderately differentiated and 38 poorly differentiated) and 76 samples of advanced colorectal adenocarcinoma (69 well-to-moderately differentiated and 7 poorly differentiated) were analyzed for p-Akt and p-caspase-9 expression by immunohistochemistry. Our results reveal a correlation between p-Akt and p-caspase-9 expression in gastric and colorectal cancers. Levels of p-caspase-9 were significantly higher in colorectal cancer than in gastric cancer, indicating tumor-specific regulation. Although the biological role of p-Akt/p-caspase-9 signaling remains unclear, we suggest that phosphorylation of caspase-9 may be a useful tool to assess the state of gastrointestinal cancer and the effects of anti-cancer therapy.

Indexed as

AdenocarcinomaAgedCaspase 9Colorectal NeoplasmsFemaleHumansImmunohistochemistryMaleMiddle AgedPhosphorylationProto-Oncogene Proteins c-aktStomach NeoplasmsCaspase 9Proto-Oncogene Proteins c-aktapoptosiscell death pathwaygastrointestinal carcinomaPhosphorylated Aktphosphorylated caspase-9

Identifiers

PMID25031754
PMCPMC4097285
OpenAlexW2300022160

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.