ArticleInternational journal of clinical and experimental pathology2014
Cytoplasmic HSP90α expression is associated with perineural invasion in pancreatic cancer.
Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Hsp90α and cell death in cancers: a review.Discover oncology · 2024Review
- Diagnostic value of HSP90α and related markers in lung cancer.Journal of clinical laboratory analysis · 2022Article
- Analysis of the prognostic, diagnostic and immunological role of HSP90α in malignant tumors.Frontiers in oncology · 2022Article
- Tumor suppressor lnc-CTSLP4 inhibits EMT and metastasis of gastric cancer by attenuating HNRNPAB-dependent Snail transcription.Molecular therapy. Nucleic acids · 2021Article
- A secretome profile indicative of oleate-induced proliferation of HepG2 hepatocellular carcinoma cells.Experimental & molecular medicine · 2018Article
- Generation of glyceraldehyde-derived advanced glycation end-products in pancreatic cancer cells and the potential of tumor promotion.World journal of gastroenterology · 2017Article
- Mining Exosomal Genes for Pancreatic Cancer Targets.Cancer genomics & proteomicsArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pancreatic cancer (PC) is an aggressive and devastating disease with a dismal prognosis. The study aimed to investigate the role of HSP90α and PDIA3 in patients with PC. Immunohistochemistry was performed on tissue microarrays containing 186 pairs of PC and normal pancreatic tissues to assess the expression levels of HSP90α and PDIA3. The expression levels of cytoplasmic HSP90α (P = 0.032) and PDIA3 (P = 0.043) in PCs were significantly higher than those in normal pancreas tissues, but nuclear HSP90α showed lower expression in PC tissues (P = 0.002). In addition, cytoplasmic expression of HSP90α and PDIA3 was significantly associated with perineural invasion (PNI) (P = 0.004) and sex (P = 0.014), respectively. These results indicate that cytoplasmic HSP90α may serve as a biomarker for PNI in PCs.
Indexed as
Identifiers
25031753PMC4097286W2281027224What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.