ArticleInternational journal of clinical and experimental pathology2014
Hypoxia-inducible factor 1 alpha contributes to pulmonary vascular dysfunction in lung ischemia-reperfusion injury.
Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Hypoxia-inducible factor-1alpha protects the liver against ischemia-reperfusion injury by regulating the A2B adenosine receptor.Bioengineered · 2021Article
- Coronavirus disease 2019 (COVID-19): Multisystem review of pathophysiology.Annals of medicine and surgery (2012) · 2021Review
- Endothelial Extracellular Vesicles: From Keepers of Health to Messengers of Disease.International journal of molecular sciences · 2021Review
- Minimizing Ischemia Reperfusion Injury in Xenotransplantation.Frontiers in immunology · 2021Review
- Review 2: Primary graft dysfunction after lung transplant-pathophysiology, clinical considerations and therapeutic targets.Journal of anesthesia · 2020Review
- Adrenomedullin serves a role in the humoral pathway of delayed remote ischemic preconditioning via a hypoxia-inducible factor-1α-associated mechanism.Molecular medicine reports · 2018Article
- Dexmedetomidine preconditioning protects against lung injury induced by ischemia-reperfusion through inhibition of autophagy.Experimental and therapeutic medicine · 2017Article
- Dexmedetomidine protects against lung ischemia-reperfusion injury by the PI3K/Akt/HIF-1α signaling pathway.Journal of anesthesia · 2016Article
- Modulatory effect of silymarin on pulmonary vascular dysfunction through HIF-1α-iNOS following rat lung ischemia-reperfusion injury.Experimental and therapeutic medicine · 2016Article
- Mechanisms of lung ischemia-reperfusion injury.Current opinion in organ transplantation · 2016Review
- Protective effects of dexamethasone on early acute lung injury induced by oleic acid in rats.International journal of clinical and experimental medicine · 2014Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The revascularization therapy of pulmonary embolism is associated with ischemia-reperfusion (IR) injury. However, the effect of IR injury on pulmonary arterial endothelial function has not been elucidated. Male Sprague-Dawley rats were divided into a control, an IR and an IR plus hypoxia-inducible factor 1 alpha (HIF-1α) stabilizer DMOG group. We found that the acetylcholine (ACh)-induced relaxation was dramatically reduced in pulmonary arteries from IR-injured rats compared with controls (P < 0.01). Interestingly, pre-treatment with the DMOG significantly improved ACh-stimulated pulmonary arterial dilatation (P < 0.01). The protein expression of HIF-1α in pulmonary artery was significantly down-regulated by IR injury (P < 0.01). Moreover, DMOG remarkably reversed IR-induced down-regulation of HIF-1α (P < 0.01). There was no difference in ACh-stimulated relaxation of endothelium-denuded or L-NMMA-treated pulmonary arteries among the three groups. The bioavailability of nitric oxide (NO) and the phosphorylation level of inducible NO synthase (iNOS) in pulmonary artery were significantly decreased by IR injury (both P < 0.01), which were reversed by DMOG (P < 0.05 or P < 0.01). In addition, the levels of superoxide in pulmonary artery were not affected by the IR injury as well as IR injury plus administration with DMOG. The present study demonstrated that HIF-1α contributes to pulmonary vascular dysfunction in lung IR injury.
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25031727PMC4097251W161585465What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.