ReviewAlzheimer's research & therapy2014
Neuroimaging in repetitive brain trauma.
Review in Alzheimer's research & therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- ADAMANT: a placebo-controlled randomized phase 2 study of AADvac1, an active immunotherapy against pathological tau in Alzheimer's disease.Nature aging · 2021Trial
- Bridging neuro-biomarkers and MR imaging: The synergistic role of glial fibrillary acidic protein in early CNS disease diagnosis.IBRO neuroscience reports · 2025Review
- Longitudinal Multimodal Magnetic Resonance Imaging Reveals Improvement in Verbal Fluency Over Time in Moderate-to-Severe Traumatic Brain Injury.Neurotrauma reports · 2025Article
- Characterization of Vasogenic and Cytotoxic Brain Edema Formation After Experimental Traumatic Brain Injury by Free Water Diffusion Magnetic Resonance Imaging.Journal of neurotrauma · 2024Article
- Article
- Diffusion tensor imaging in the courtroom: Distinction between scientific specificity and legally admissible evidence.World journal of clinical cases · 2023Review
- Transcranial Photobiomodulation Treatment: Significant Improvements in Four Ex-Football Players with Possible Chronic Traumatic Encephalopathy.Journal of Alzheimer's disease reports · 2023Article
- Cerebral and cognitive modifications in retired professional soccer players: TC-FOOT protocol, a transverse analytical study.BMJ open · 2022Article
- Identifying degenerative effects of repetitive head trauma with neuroimaging: a clinically-oriented review.Acta neuropathologica communications · 2021Review
- Resting-State Static and Dynamic Functional Abnormalities in Active Professional Fighters With Repetitive Head Trauma and With Neuropsychological Impairments.Frontiers in neurology · 2020Article
- Understanding white matter structural connectivity differences between cognitively impaired and nonimpaired active professional fighters.Human brain mapping · 2019Article
- Emerging advances of in vivo detection of chronic traumatic encephalopathy and traumatic brain injury.The British journal of radiology · 2019Review
- Low Prefrontal GABA Levels Are Associated With Poor Cognitive Functions in Professional Boxers.Frontiers in human neuroscience · 2019Article
- MRI-defined White Matter Microstructural Alteration Associated with Soccer Heading Is More Extensive in Women than Men.Radiology · 2018Article
- Age of first exposure to tackle football and chronic traumatic encephalopathy.Annals of neurology · 2018Article
- Investigating structural and perfusion deficits due to repeated head trauma in active professional fighters.NeuroImage. Clinical · 2018Article
- Automated versus manual segmentation of brain region volumes in former football players.NeuroImage. Clinical · 2018Article
- Multimodal MR Imaging Signatures of Cognitive Impairment in Active Professional Fighters.Radiology · 2017Article
- Subconcussive impacts and imaging findings over a season of contact sports.Concussion (London, England) · 2016Review
- Modulation of Neural Network Activity through Single Cell Ablation: An in Vitro Model of Minimally Invasive Neurosurgery.Molecules (Basel, Switzerland) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Sports-related concussions are one of the major causes of mild traumatic brain injury. Although most patients recover completely within days to weeks, those who experience repetitive brain trauma (RBT) may be at risk for developing a condition known as chronic traumatic encephalopathy (CTE). While this condition is most commonly observed in athletes who experience repetitive concussive and/or subconcussive blows to the head, such as boxers, football players, or hockey players, CTE may also affect soldiers on active duty. Currently, the only means by which to diagnose CTE is by the presence of phosphorylated tau aggregations post-mortem. Non-invasive neuroimaging, however, may allow early diagnosis as well as improve our understanding of the underlying pathophysiology of RBT. The purpose of this article is to review advanced neuroimaging methods used to investigate RBT, including diffusion tensor imaging, magnetic resonance spectroscopy, functional magnetic resonance imaging, susceptibility weighted imaging, and positron emission tomography. While there is a considerable literature using these methods in brain injury in general, the focus of this review is on RBT and those subject populations currently known to be susceptible to RBT, namely athletes and soldiers. Further, while direct detection of CTE in vivo has not yet been achieved, all of the methods described in this review provide insight into RBT and will likely lead to a better characterization (diagnosis), in vivo, of CTE than measures of self-report.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.