Evidence map›Paper›PMID 25031607›Full record

ArticleExpert review of ophthalmology2014

Nerve growth factor in diabetic retinopathy: beyond neurons.

Barbara A Mysona, Ahmed Y Shanab, Sally L Elshaer, Azza B El-Remessy

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Expert review of ophthalmology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
1.8field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Neuroprotection in Diabetes Retinal Disease: An Unmet Medical Need.International journal of molecular sciences · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. The innate immune system in diabetic retinopathy.Progress in retinal and eye research · 2021
    Review
  16. Article
  17. Article
  18. Review
  19. Effect of topical administration of the microneurotrophin BNN27 in the diabetic rat retina.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Barbara A MysonaProgram in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA, USA and Culver Vision Discovery Institute, Georgia Regents University, Augusta, GA, USA and Charlie Norwood Veterans Affairs Medical Center, Augusta, GA, USA.
Ahmed Y ShanabProgram in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA, USA and Culver Vision Discovery Institute, Georgia Regents University, Augusta, GA, USA and Charlie Norwood Veterans Affairs Medical Center, Augusta, GA, USA.
Sally L ElshaerProgram in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA, USA and Culver Vision Discovery Institute, Georgia Regents University, Augusta, GA, USA and Charlie Norwood Veterans Affairs Medical Center, Augusta, GA, USA.
Azza B El-RemessyProgram in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA, USA and Culver Vision Discovery Institute, Georgia Regents University, Augusta, GA, USA and Charlie Norwood Veterans Affairs Medical Center, Augusta, GA, USA.
Augusta University Health · USCharlie Norwood VA Medical Center · US

Funding

Molecular Mechanisms of diabetic retinopathyR01EY022408 · NEI · UNIVERSITY OF GEORGIA · PI EL-REMESSY, AZZA B · 2012 to 2016
$1.5M
NEI NIH HHS R01 EY022408
6 · The paper itself

Abstract

Diabetic retinopathy (DR), a major ocular complication of diabetes, is a leading cause of blindness in US working age adults with limited treatments. Neurotrophins (NTs), a family of proteins essential for growth, differentiation and survival of retinal neurons, have emerged as potential players in the pathogenesis of DR. NTs can signal through their corresponding tropomyosin kinase related receptor to mediate cell survival or through the p75 neurotrophin receptor with the co-receptor, sortilin, to mediate cell death. This review focuses on the role of NGF, the first discovered NT, in the development of DR. Impaired processing of proNGF has been found in ocular fluids from diabetic patients as well as experimental models. Evidence from literature and our studies support the notion that NTs appear to play multiple potential roles in DR, hence, understanding their contribution to DR may lead to promising therapeutic approaches for this devastating disease.

Indexed as

acellular capillaryangiogenesisdiabetic macular edemadiabetic retinopathyinflammationneurodegenerationneurotrophinsp75NTR

Identifiers

PMID25031607
PMCPMC4096131
OpenAlexW1994117565

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.