ReviewHepatitis monthly2014
Interleukin 18 gene promoter polymorphisms and susceptibility to chronic hepatitis B infection: a review study.
Review in Hepatitis monthly, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- TheFrontiers in immunology · 2023Pooled it
- IL-6 and IL-10 gene polymorphisms and cirrhosis of liver risk from a comprehensive analysis.BMC endocrine disorders · 2021Pooled it
- The Protective Role of Haplotype -607A/-137C in the Promoter Region of IL-18 Gene and HBV Infection Risk in the North Indian Population.Combinatorial chemistry & high throughput screening · 2026Article
- Associations between circulating interleukin-18 levels and adult-onset Still's disease: a meta-analysis.Journal of rheumatic diseases · 2025Article
- Genetic Markers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease.Metabolites · 2023Review
- Polymorphism Analysis of Interleukin-18 and Interleukin-37 Genes in Hepatitis B Infections with Different Outcomes: A Preliminary Report from an Iranian Population.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Comprehensive investigating of mismatch repair genes (MMR) polymorphisms in participants with chronic hepatitis B virus infection.Frontiers in genetics · 2023Article
- The IL-18, IL-12, and IFN-γ expression in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients, HTLV-1 carriers, and healthy subjects.Journal of neurovirology · 2020Article
- Interleukin-18 in Health and Disease.International journal of molecular sciences · 2019Review
- Multiple genetic variants associated with posttransplantation diabetes mellitus in Chinese Han populations.Journal of clinical laboratory analysis · 2018Article
- [Association between IL-19 gene polymorphisms and hepatitis B virus susceptibility in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Article
- [Clinical value of fluorescence lateral flow immunoassay in diagnosis of influenza A in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Article
- Manipulation of Regulatory Cells' Responses to Treatments for Chronic Hepatitis B Virus Infection.Hepatitis monthly · 2016Article
- Crosstalk between innate and adaptive immunity in hepatitis B virus infection.World journal of hepatology · 2015Review
- Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Gene Polymorphisms and Hepatitis B Virus Infection.Jundishapur journal of microbiology · 2015Article
- Impact of the IL-10 Promoter Gene Polymorphisms in the Severity of Chronic Hepatitis B Infection.Hepatitis monthly · 2015Article
- Association between interleukin-18 gene polymorphism and Helicobacter pylori infection in the Korean population.Scientific reports · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextThe variation in clinical outcome of hepatitis B virus (HBV) infection is determined by virological, immunological and host genetic factors. Genes encoding cytokines are one of the candidates among host genetic factors. Polymorphisms in gene promoter can lead to different levels of cytokine expression and unique immune response. Being involved in the inflammatory cytokine network, interleukin-18 (IL-18) plays an important role in pathogenesis of HBV infection. The aim of this review is considering available literature on the association between IL-18 gene promoter single nucleotide polymorphisms (-137 C/G and -607 A/C) and susceptibility to chronic HBV infection. EVIDENCE ACQUISITION: Published literature from PubMed, EMBASE, and other databases were retrieved. All studies investigating the association of IL-18 gene promoter SNPs, -137 C/G and -607 A/C, with susceptibility to chronic HBV infection were included.
resultsFindings showed that the genotype -607A/A is associated with the susceptibility to chronic hepatitis B. Furthermore, allele C at position -137 is suggested to play a protective role against development of chronic HBV infection.
conclusionsHost genetic factors play an important role in determining the outcome of HBV infection. It is suggested that IL-18 genotype -607 A/A is associated with susceptibility to chronic hepatitis B. Furthermore, the carriage of allele C at position -137 may play a protective role in the development of chronic HBV infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.