Evidence map›Paper›PMID 25031534›Full record

ArticleInternational journal of nanomedicine2014

Abdominal closure reinforcement by using polypropylene mesh functionalized with poly-ε-caprolactone nanofibers and growth factors for prevention of incisional hernia formation.

Martin Plencner, Barbora East, Zbyněk Tonar, Martin Otáhal, Eva Prosecká, Michala Rampichová, Tomáš Krejčí, Andrej Litvinec, Matej Buzgo, Andrea Míčková and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
  2. Histochemistry for Molecular Imaging in Nanomedicine.International journal of molecular sciences · 2024
    Review
  3. Biodegradable Polymers in Veterinary Medicine-A Review.Molecules (Basel, Switzerland) · 2024
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Liquid resorbable nanofibrous surgical mesh: a proof of a concept.Hernia : the journal of hernias and abdominal wall surgery · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Frontiers in bioengineering and biotechnology · 2020
    Article
  13. Article
  14. Dynamic creep properties of a novel nanofiber hernia mesh in abdominal wall repair.Hernia : the journal of hernias and abdominal wall surgery · 2019
    Article
  15. Long-term outcomes after prophylactic use of onlay mesh in midline laparotomy.Hernia : the journal of hernias and abdominal wall surgery · 2018
    Observational
  16. Article
  17. Article
  18. Review
  19. Article
  20. Mesh implants: An overview of crucial mesh parameters.World journal of gastrointestinal surgery · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Martin PlencnerInstitute of Biophysics, Second Faculty of Medicine, Charles University in Prague, Prague, Czech Republic ; Laboratory of Tissue Engineering, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Barbora EastDepartment of Surgery, Second Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
Zbyněk TonarBiomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic.
Martin OtáhalDepartment of Anatomy and Biomechanics, Faculty of Physical Education and Sport, Charles University in Prague, Prague, Czech Republic.
Eva ProseckáInstitute of Biophysics, Second Faculty of Medicine, Charles University in Prague, Prague, Czech Republic ; Laboratory of Tissue Engineering, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Michala RampichováLaboratory of Tissue Engineering, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic ; University Center for Energy Efficient Buildings, Czech Technical University in Prague, Buštěhrad, Czech Republic.
Tomáš KrejčíDepartment of Surgery, Second Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
Andrej LitvinecLaboratory of Tissue Engineering, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic ; Department of Breeding and Zoohygiene of Laboratory Animals, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Matej BuzgoLaboratory of Tissue Engineering, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic ; University Center for Energy Efficient Buildings, Czech Technical University in Prague, Buštěhrad, Czech Republic.
Andrea MíčkováInstitute of Biophysics, Second Faculty of Medicine, Charles University in Prague, Prague, Czech Republic ; Laboratory of Tissue Engineering, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic ; University Center for Energy Efficient Buildings, Czech Technical University in Prague, Buštěhrad, Czech Republic.
Alois NečasDepartment of Surgery and Orthopedics, Small Animal Clinic, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Science Brno, Central European Institute of Technology, Brno, Czech Republic.
Jiří HochDepartment of Surgery, Second Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
Evžen AmlerInstitute of Biophysics, Second Faculty of Medicine, Charles University in Prague, Prague, Czech Republic ; Laboratory of Tissue Engineering, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic ; Faculty of Biomedical Engineering, Czech Technical University in Prague, Kladno, Czech Republic.
Charles University · CZCzech Academy of Sciences · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Incisional hernia affects up to 20% of patients after abdominal surgery. Unlike other types of hernia, its prognosis is poor, and patients suffer from recurrence within 10 years of the operation. Currently used hernia-repair meshes do not guarantee success, but only extend the recurrence-free period by about 5 years. Most of them are nonresorbable, and these implants can lead to many complications that are in some cases life-threatening. Electrospun nanofibers of various polymers have been used as tissue scaffolds and have been explored extensively in the last decade, due to their low cost and good biocompatibility. Their architecture mimics the natural extracellular matrix. We tested a biodegradable polyester poly-ε-caprolactone in the form of nanofibers as a scaffold for fascia healing in an abdominal closure-reinforcement model for prevention of incisional hernia formation. Both in vitro tests and an experiment on a rabbit model showed promising results.

Indexed as

3T3 CellsAbdomenAbdominal Wound Closure TechniquesAnimalsBiomechanical PhenomenaGuided Tissue RegenerationHerniaHistocytochemistryIntercellular Signaling Peptides and ProteinsMiceNanofibersPolyestersPolypropylenesPostoperative ComplicationsRabbitsSurgical MeshIntercellular Signaling Peptides and ProteinspolycaprolactonePolyestersPolypropylenesgrowth factorshernia regenerationin vivonanofiberssurgical mesh

Identifiers

PMID25031534
PMCPMC4096451
OpenAlexW2012740752

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.