Evidence map›Paper›PMID 25031442›Full record

ArticleJournal of clinical microbiology2014

Genetic and molecular predictors of high vancomycin MIC in Staphylococcus aureus bacteremia isolates.

Natasha E Holmes, John D Turnidge, Wendy J Munckhof, J Owen Robinson, Tony M Korman, Matthew V N O'Sullivan, Tara L Anderson, Sally A Roberts, Sanchia J C Warren, Geoffrey W Coombs and 4 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
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  7. Clonal Diversity and Epidemiological Characteristics of ST239-MRSA Strains.Frontiers in cellular and infection microbiology · 2022
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Vancomycin MICs and risk of complicated bacteremia by glycopeptide-susceptible Staphylococcus aureus.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Global Scale Dissemination of ST93: A DivergentFrontiers in microbiology · 2018
    Article
  20. Pathogen-related factors affecting outcome of catheter-related bacteremia due to methicillin-susceptible Staphylococcus aureus in a Spanish multicenter study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 2 countries.

Natasha E HolmesAustin Centre for Infection Research, Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia Department of Medicine, University of Melbourne, Parkville, Victoria, Australia natasha.holmes@austin.org.au.
John D TurnidgeSA Pathology, Women's and Children's Hospital, North Adelaide, South Australia, Australia Department of Paediatrics, Pathology and Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia, Australia.
Wendy J MunckhofInfection Management Services, Princess Alexandra Hospital, Wolloongabba, Queensland, Australia Department of Medicine, University of Queensland, St Lucia, Queensland, Australia.
J Owen RobinsonDepartment of Microbiology and Infectious Diseases, PathWest Laboratory Medicine-WA, Royal Perth Hospital, Perth, Western Australia, Australia Australian Collaborating Centre for Enterococcus and Staphylococcus Species (ACCESS) Typing and Research, School of Biomedical Sciences, Curtin University, Perth, Western Australia, Australia.
Tony M KormanDepartment of Infectious Diseases, Monash Health, Clayton, Victoria, Australia Department of Medicine, Monash University, Clayton, Victoria, Australia.
Matthew V N O'SullivanCentre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, New South Wales, Australia Department of Medicine, University of Sydney, Sydney, New South Wales, Australia.
Tara L AndersonDepartment of Infectious Diseases, Royal Hobart Hospital, Hobart, Tasmania, Australia Department of Medicine, University of Tasmania, Hobart, Tasmania, Australia.
Sally A RobertsAuckland District Health Board, Auckland, New Zealand.
Sanchia J C WarrenDepartment of Infectious Diseases, Royal Hobart Hospital, Hobart, Tasmania, Australia Department of Medicine, University of Tasmania, Hobart, Tasmania, Australia.
Geoffrey W CoombsDepartment of Microbiology and Infectious Diseases, PathWest Laboratory Medicine-WA, Royal Perth Hospital, Perth, Western Australia, Australia Australian Collaborating Centre for Enterococcus and Staphylococcus Species (ACCESS) Typing and Research, School of Biomedical Sciences, Curtin University, Perth, Western Australia, Australia.
Hui-Leen TanDepartment of Microbiology and Infectious Diseases, PathWest Laboratory Medicine-WA, Royal Perth Hospital, Perth, Western Australia, Australia Australian Collaborating Centre for Enterococcus and Staphylococcus Species (ACCESS) Typing and Research, School of Biomedical Sciences, Curtin University, Perth, Western Australia, Australia.
Wei GaoAustin Centre for Infection Research, Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia Department of Microbiology, Austin Health, Heidelberg, Victoria, Australia.
Paul D R JohnsonAustin Centre for Infection Research, Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia Department of Medicine, University of Melbourne, Parkville, Victoria, Australia Department of Microbiology, Monash University, Clayton, Victoria, Australia.
Benjamin P HowdenAustin Centre for Infection Research, Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia Department of Microbiology, Austin Health, Heidelberg, Victoria, Australia Department of Microbiology, Monash University, Clayton, Victoria, Australia Microbiological Diagnostic Unit, Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
Austin Health · AUMonash University · AURoyal Perth Hospital · AUAuckland District Health Board · NZCurtin University · AURoyal Hobart Hospital · AUSouth Australia Pathology · AUThe University of Melbourne · AUThe University of Queensland · AUThe University of Sydney · AUUniversity of Tasmania · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An elevated vancomycin MIC is associated with poor outcomes in Staphylococcus aureus bacteremia (SAB) and is reported in patients with methicillin-susceptible S. aureus (MSSA) bacteremia in the absence of vancomycin treatment. Here, using DNA microarray and phenotype analysis, we investigated the genetic predictors and accessory gene regulator (agr) function and their relationship with elevated vancomycin MIC using blood culture isolates from a multicenter binational cohort of patients with SAB. Specific clonal complexes were associated with elevated (clonal complex 8 [CC8] [P < 0.001]) or low (CC22 [P < 0.001], CC88 [P < 0.001], and CC188 [P = 0.002]) vancomycin MIC. agr dysfunction (P = 0.014) or agr genotype II (P = 0.043) were also associated with an elevated vancomycin MIC. Specific resistance and virulence genes were also linked to an elevated vancomycin MIC, including blaZ (P = 0.002), sea (P < 0.001), clfA (P < 0.001), splA (P = 0.001), and the arginine catabolic mobile element (ACME) locus (P = 0.02). These data suggest that inherent organism characteristics may explain the link between elevated vancomycin MICs and poor outcomes in patients with SAB, regardless of the antibiotic treatment received. A consideration of clonal specificity should be included in future research when attempting to ascertain treatment effects or clinical outcomes.

Indexed as

Drug ToleranceAdolescentAdultAgedAnti-Bacterial AgentsBacteremiaBacterial ProteinsChildChild, PreschoolCohort StudiesFemaleGenotypeHumansInfantInfant, NewbornMaleAgr protein, Staphylococcus aureusAnti-Bacterial AgentsBacterial ProteinsTrans-ActivatorsVancomycinVirulence Factors

Identifiers

PMID25031442
PMCPMC4313166
OpenAlexW2118503769

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.