ArticleMolecular biology of the cell2014
Cordon Bleu serves as a platform at the basal region of microvilli, where it regulates microvillar length through its WH2 domains.
Article in Molecular biology of the cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Identification of Missense Variants Affecting Carcass Traits for Hanwoo Precision Breeding.Genes · 2023Article
- Building the brush border, one microvillus at a time.Current opinion in cell biology · 2023Review
- Functional Mimicry of Eukaryotic Actin Assembly by Pathogen Effector Proteins.International journal of molecular sciences · 2022Review
- Simultaneous stabilization of actin cytoskeleton in multiple nephron-specific cells protects the kidney from diverse injury.Nature communications · 2022Article
- PACSIN proteins in vivo: Roles in development and physiology.Acta physiologica (Oxford, England) · 2022Review
- The actin nucleator Cobl organises the terminal web of enterocytes.Scientific reports · 2020Article
- Profilin-Mediated Actin Allocation Regulates the Growth of Epithelial Microvilli.Current biology : CB · 2019Article
- Actin Dynamics Drive Microvillar Motility and Clustering during Brush Border Assembly.Developmental cell · 2019Article
- PACSIN2-dependent apical endocytosis regulates the morphology of epithelial microvilli.Molecular biology of the cell · 2019Article
- Regulation of actin-based apical structures on epithelial cells.Journal of cell science · 2018Review
- IRTKS (BAIAP2L1) Elongates Epithelial Microvilli Using EPS8-Dependent and Independent Mechanisms.Current biology : CB · 2018Article
- Ependymal cilia beating induces an actin network to protect centrioles against shear stress.Nature communications · 2018Article
- COBLL1 modulates cell morphology and facilitates androgen receptor genomic binding in advanced prostate cancer.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- A urine-dependent human urothelial organoid offers a potential alternative to rodent models of infection.Scientific reports · 2018Article
- MyTH4-FERM myosins in the assembly and maintenance of actin-based protrusions.Current opinion in cell biology · 2017Review
- Validation of Single Nucleotide Polymorphisms Associated with Carcass Traits in a Commercial Hanwoo Population.Asian-Australasian journal of animal sciences · 2016Article
- Impact of cordon-bleu expression on actin cytoskeleton architecture and dynamics.Cytoskeleton (Hoboken, N.J.) · 2016Article
- Review
- The WH2 Domain and Actin Nucleation: Necessary but Insufficient.Trends in biochemical sciences · 2016Review
- Cordon bleu promotes the assembly of brush border microvilli.Molecular biology of the cell · 2015Article
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Abstract
Cordon Bleu (Cobl) is a WH2-containing protein believed to act as an actin nucleator. We show that it has a very specific localization in epithelial cells at the basal region of microvilli, a localization unlikely to be involved in actin nucleation. The protein is localized by a central region between the N-terminal COBL domain and the three C-terminal WH2 domains. Ectopic expression of Cobl shortens apical microvilli, and this requires functional WH2 domains. Proteomic studies reveal that the COBL domain binds several BAR-containing proteins, including SNX9, PACSIN 2/syndapin 2, and ASAP1. ASAP1 is recruited to the base of microvilli by binding the COBL domain through its SH3. We propose that Cobl is localized to the basal region of microvilli both to participate in length regulation and to recruit BAR proteins that associate with the curved membrane found at the microvillar base.
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