ArticleMolecular biology of the cell2014
Drosophila pericentrin requires interaction with calmodulin for its function at centrosomes and neuronal basal bodies but not at sperm basal bodies.
Article in Molecular biology of the cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 48 citations in OpenAlex.
- A MOPD II-associated Pericentrin variant disrupts PACT domain dimerization and pericentriolar material recruitment.bioRxiv : the preprint server for biology · 2026Article
- Review
- The PCM scaffold enables RNA localization to centrosomes.Molecular biology of the cell · 2025Article
- A deficiency screen identifies genomic regions critical for sperm head-tail connection.G3 (Bethesda, Md.) · 2025Article
- Fly Fam161 is an essential centriole and cilium transition zone protein with unique and diverse cell type-specific localizations.Open biology · 2024Article
- A deficiency screen identifies genomic regions critical for sperm head-tail connection.bioRxiv : the preprint server for biology · 2024Article
- The core spindle pole body scaffold Ppc89 links the pericentrin orthologue Pcp1 to the fission yeast spindle pole body via an evolutionarily conserved interface.Molecular biology of the cell · 2024Article
- Positioning centrioles and centrosomes.The Journal of cell biology · 2024Review
- The E3 ligase Poe promotes Pericentrin degradation.Molecular biology of the cell · 2023Article
- Spd-2 gene duplication reveals cell-type-specific pericentriolar material regulation.Current biology : CB · 2023Article
- Piezo mechanosensory channels regulate centrosome integrity and mitotic entry.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Pericentrin interacts with Kinesin-1 to drive centriole motility.The Journal of cell biology · 2022Article
- Orb-dependent polyadenylation contributes to PLP expression and centrosome scaffold assembly.Development (Cambridge, England) · 2022Article
- Drosophila centrocortin is dispensable for centriole duplication but contributes to centrosome separation.G3 (Bethesda, Md.) · 2022Article
- CEP290 is essential for the initiation of ciliary transition zone assembly.PLoS biology · 2020Article
- Phosphorylation of NMDA receptors by cyclin B/CDK1 modulates calcium dynamics and mitosis.Communications biology · 2020Article
- Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling.Molecular cell · 2020Article
- Primary cilia control glucose homeostasis via islet paracrine interactions.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Sperm Head-Tail Linkage Requires Restriction of Pericentriolar Material to the Proximal Centriole End.Developmental cell · 2020Article
- Drosophila pericentrin-like protein promotes the formation of primordial germ cells.Genesis (New York, N.Y. : 2000) · 2020Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Pericentrin is a critical centrosomal protein required for organizing pericentriolar material (PCM) in mitosis. Mutations in pericentrin cause the human genetic disorder Majewski/microcephalic osteodysplastic primordial dwarfism type II, making a detailed understanding of its regulation extremely important. Germaine to pericentrin's function in organizing PCM is its ability to localize to the centrosome through the conserved C-terminal PACT domain. Here we use Drosophila pericentrin-like-protein (PLP) to understand how the PACT domain is regulated. We show that the interaction of PLP with calmodulin (CaM) at two highly conserved CaM-binding sites in the PACT domain controls the proper targeting of PLP to the centrosome. Disrupting the PLP-CaM interaction with single point mutations renders PLP inefficient in localizing to centrioles in cultured S2 cells and Drosophila neuroblasts. Although levels of PCM are unaffected, it is highly disorganized. We also demonstrate that basal body formation in the male testes and the production of functional sperm does not rely on the PLP-CaM interaction, whereas production of functional mechanosensory neurons does.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.