ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
A new pathway mediating social effects on the endocrine system: female presence acting via norepinephrine release stimulates gonadotropin-inhibitory hormone in the paraventricular nucleus and suppresses luteinizing hormone in quail.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 62 citations in OpenAlex.
- Gonadotropin-Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress-Induced Activation of the Locus Coeruleus-SAM Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Divergent projections from locus coeruleus to the corticobasal ganglia system and ventral tegmental area of the adult male zebra finch.The Journal of comparative neurology · 2023Article
- Impact of stress on male fertility: role of gonadotropin inhibitory hormone.Frontiers in endocrinology · 2023Review
- For the physiology of cooperative breeding, it's time to move beyond stress: A Comment on: 'Stress in an underground empire' (2022) by Medger.Biology letters · 2022Article
- Female presence does not increase testosterone but still ameliorates sickness behaviours in male Japanese quail.Royal Society open science · 2022Article
- Review
- Ontogeny of OPN4, OPN5, GnRH and GnIH mRNA Expression in the Posthatch Male and Female Pekin Duck (Animals : an open access journal from MDPI · 2021Article
- Effects of Social Information on the Release and Expression of Gonadotropin-Inhibitory Hormone in Birds.Frontiers in endocrinology · 2019Review
- Electro-Acupuncture Affects the Activity of the Hypothalamic-Pituitary-Ovary Axis in Female Rats.Frontiers in physiology · 2019Article
- Editorial: Progress in Reproductive Neuroendocrinology in Vertebrates.Frontiers in endocrinology · 2019Article
- Comparative and Evolutionary Aspects of Gonadotropin-Inhibitory Hormone and FMRFamide-Like Peptide Systems.Frontiers in neuroscience · 2018Article
- How to Contribute to the Progress of Neuroendocrinology: Discovery of GnIH and Progress of GnIH Research.Frontiers in endocrinology · 2018Review
- The Preoptic Area and the RFamide-Related Peptide Neuronal System Gate Seasonal Changes in Chemosensory Processing.Integrative and comparative biology · 2017Article
- GnIH Control of Feeding and Reproductive Behaviors.Frontiers in endocrinology · 2016Review
- Reproductive Neuroendocrine Pathways of Social Behavior.Frontiers in endocrinology · 2016Review
- Seasonal control of gonadotropin-inhibitory hormone (GnIH) in birds and mammals.Frontiers in neuroendocrinology · 2015Review
- Contribution of GnIH Research to the Progress of Reproductive Neuroendocrinology.Frontiers in endocrinology · 2015Review
- Review: neuroestrogen regulation of socio-sexual behavior of males.Frontiers in neuroscience · 2014Review
- Testing hormonal responses to real and simulated social challenges in a competitive female bird.Behavioral ecology : official journal of the International Society for Behavioral EcologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rapid effects of social interactions on transient changes in hormonal levels are known in a wide variety of vertebrate taxa, ranging from fish to humans. Although these responses are mediated by the brain, neurochemical pathways that translate social signals into reproductive physiological changes are unclear. In this study, we analyzed how a female presence modifies synthesis and/or release of various neurochemicals, such as monoamines and neuropeptides, in the brain and downstream reproductive hormones in sexually active male Japanese quail. By viewing a female bird, sexually active males rapidly increased norepinephrine (NE) release in the paraventricular nucleus (PVN) of the hypothalamus, in which gonadotropin-inhibitory hormone (GnIH) neuronal cell bodies exist, increased GnIH precursor mRNA expression in the PVN, and decreased luteinizing hormone (LH) concentration in the plasma. GnIH is a hypothalamic neuropeptide that inhibits gonadotropin secretion from the pituitary. It was further shown that GnIH can rapidly suppress LH release after intravenous administration in this study. Centrally administered NE decreased plasma LH concentration in vivo. It was also shown that NE stimulated the release of GnIH from diencephalic tissue blocks in vitro. Fluorescence double-label immunohistochemistry indicated that GnIH neurons received noradrenergic innervations, and immunohistochemistry combined with in situ hybridization have further shown that GnIH neurons expressed α2A-adrenergic receptor mRNA. These results indicate that a female presence increases NE release in the PVN and stimulates GnIH release, resulting in the suppression of LH release in sexually active male quail.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.