ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
A leptin-mediated central mechanism in analgesia-enhanced opioid reward in rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Interactions of pain and opioids on conditioned place preference in rodents.Psychopharmacology · 2025Review
- Chronic inflammatory pain reduces fentanyl intake during early acquisition of fentanyl self-administration, but does not change motivation to take fentanyl in male and female rats.Pharmacology, biochemistry, and behavior · 2024Article
- The effects of chronic neuropathic pain on the self-administration of highly potent MOR agonist, fentanyl.bioRxiv : the preprint server for biology · 2024Article
- An Ascending Excitatory Circuit from the Dorsal Raphe for Sensory Modulation of Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Chronic inflammatory pain promotes place preference for fentanyl in male rats but does not change fentanyl self-administration in male and female rats.Neuropharmacology · 2023Article
- Neuroinflammatory Response in Reward-Associated Psychostimulants and Opioids: A Review.Cellular and molecular neurobiology · 2023Review
- Contributions of neuroimmune and gut-brain signaling to vulnerability of developing substance use disorders.Neuropharmacology · 2021Review
- The role of gut-immune-brain signaling in substance use disorders.International review of neurobiology · 2021Article
- Methylphenidate and Morphine Combination Therapy in a Rat Model of Chronic Pain.Anesthesia and analgesia · 2020Article
- Glial neuroimmune signaling in opioid reward.Brain research bulletin · 2020Review
- Incisional Injury Modulates Morphine Reward and Morphine-Primed Reinstatement: A Role of Kappa Opioid Receptor Activation.Anesthesia and analgesia · 2020Article
- Interactions between pain states and opioid reward assessed with intracranial self-stimulation in rats.Neuropharmacology · 2019Review
- Article
- Nortriptyline Enhances Morphine-Conditioned Place Preference in Neuropathic Rats: Role of the Central Noradrenergic System.Anesthesia and analgesia · 2017Article
- Animal models of rheumatoid pain: experimental systems and insights.Arthritis research & therapy · 2017Review
- Mesolimbic leptin signaling negatively regulates cocaine-conditioned reward.Translational psychiatry · 2016Article
- Modulation of pain, nociception, and analgesia by the brain reward center.Neuroscience · 2016Review
- Article
- Integration of reward signalling and appetite regulating peptide systems in the control of food-cue responses.British journal of pharmacology · 2015Review
- The positive effect on ketamine as a priming adjuvant in antidepressant treatment.Translational psychiatry · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Opioid analgesics are commonly used in chronic pain management despite a potential risk of rewarding. However, it remains unclear whether opioid analgesia would enhance the opioid rewarding effect thereby contributing to opioid rewarding. Utilizing a rat paradigm of conditioned place preference (CPP) combined with ankle monoarthritis as a condition of persistent nociception, we showed that analgesia induced by either morphine or the nonsteroid anti-inflammatory drug ibuprofen increased CPP scores in arthritic rats, suggesting that analgesia itself had a rewarding effect. However, arthritic rats exhibited a significantly higher CPP score in response to morphine than ibuprofen. Thus, the rewarding effect of morphine was enhanced in the presence of persistent nociception, producing a phenomenon of analgesia-enhanced opioid reward. At the cellular level, administration of morphine activated a cascade of leptin expression, glial activation, and dopamine receptor upregulation in the nucleus accumbens (NAc), while administration of ibuprofen decreased glial activation with no effect on leptin expression in the NAc. Furthermore, the morphine rewarding effect was blocked in leptin deficient ob/ob mice or by neutralizing leptin or interleukin-1β in the NAc without diminishing morphine analgesia. The data indicate that systemic opioid can activate a leptin-mediated central mechanism in the NAc that led to the enhanced opioid rewarding effect. These findings provide evidence for an interaction between opioid analgesia and opioid rewarding, which may have implications in clinical opioid dose escalation in chronic pain management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.