Evidence map›Paper›PMID 25031401›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014

N-cadherin promotes recruitment and migration of neural progenitor cells from the SVZ neural stem cell niche into demyelinated lesions.

Michael Klingener, Manideep Chavali, Jagdeep Singh, Nadia McMillan, Alexandra Coomes, Peter J Dempsey, Emily I Chen, Adan Aguirre

RetractedOpen access · bronzeAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. A Valuable Target for Therapy: The Metalloproteinase ADAM10.Current protein & peptide science · 2025
    Review
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  6. Urokinase-type plasminogen activator promotes N-cadherin-mediated synaptic recovery in the ischemic brain.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
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  9. DCXScientific reports · 2020
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Michael KlingenerState University of New York at Stony Brook University, Departments of Pharmacological Science and.
Manideep ChavaliState University of New York at Stony Brook University, Departments of Pharmacological Science and Materials Science and Engineering, Stony Brook, New York 11794.
Jagdeep SinghState University of New York at Stony Brook University, Departments of Pharmacological Science and.
Nadia McMillanState University of New York at Stony Brook University, Departments of Pharmacological Science and.
Alexandra CoomesState University of New York at Stony Brook University, Departments of Pharmacological Science and Stony Brook University Proteomics Center, School of Medicine, Stony Brook, New York 11794.
Peter J DempseyDepartment of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan 48109, and.
Emily I ChenState University of New York at Stony Brook University, Departments of Pharmacological Science and Stony Brook University Proteomics Center, School of Medicine, Stony Brook, New York 11794.
Adan AguirreState University of New York at Stony Brook University, Departments of Pharmacological Science and adan.aguirre@stonybrook.edu.
University of Michigan–Ann Arbor · US

Funding

ADAM10 in Intestinal Homeostasis and RegenerationR01DK093697 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DEMPSEY, PETER J · 2012 to 2016
$1.5M
ROLE OF NG2 CELLS IN THE MAINTENANCE OF THE SUBVENTRICULAR ZONE NICHER00NS057944 · NINDS · STATE UNIVERSITY NEW YORK STONY BROOK · PI AGUIRRE, ADAN A · 2010 to 2012
$707k
NIDDK NIH HHS R01 DK093697NINDS NIH HHS 4R00NS057944-03NINDS NIH HHS R00 NS057944
6 · The paper itself

Abstract

Discrete cellular microenvironments regulate stem cell pools and their development, as well as function in maintaining tissue homeostasis. Although the signaling elements modulating neural progenitor cells (NPCs) of the adult subventricular zone (SVZ) niche are fairly well understood, the pathways activated following injury and the resulting outcomes, are less clear. In the present study, we used mouse models of demyelination and proteomics analysis to identify molecular cues present in the adult SVZ niche during injury, and analyzed their role on NPCs in the context of promoting myelin repair. Proteomic analysis of SVZ tissue from mice with experimental demyelination identified several proteins that are known to play roles in NPC proliferation, adhesion, and migration. Among the proteins found to be upregulated were members of the N-cadherin signaling pathway. During the onset of demyelination in the subcortical white matter (SCWM), activation of epidermal growth factor receptor (EGFR) signaling in SVZ NPCs stimulates the interaction between N-cadherin and ADAM10. Upon cleavage and activation of N-cadherin signaling by ADAM10, NPCs undergo cytoskeletal rearrangement and polarization, leading to enhanced migration out of the SVZ into demyelinated lesions of the SCWM. Genetically disrupting either EGFR signaling or ADAM10 inhibits this pathway, preventing N-cadherin regulated NPC polarization and migration. Additionally, in vivo experiments using N-cadherin gain- and loss-of-function approaches demonstrated that N-cadherin enhances the recruitment of SVZ NPCs into demyelinated lesions. Our data revealed that EGFR-dependent N-cadherin signaling physically initiated by ADAM10 cleavage is the response of the SVZ niche to promote repair of the injured brain.

Indexed as

2',3'-Cyclic Nucleotide 3'-PhosphodiesteraseAnimalsAntigensCadherinsCell AdhesionCell MovementChondroitin Sulfate Proteoglycan 4Demyelinating DiseasesDisease Models, AnimalEpidermal Growth FactorGene Expression RegulationLateral VentriclesMiceMice, TransgenicMyelin ProteinsNeural Stem Cells2',3'-Cyclic Nucleotide 3'-PhosphodiesteraseAntigensCadherinsChondroitin Sulfate Proteoglycan 4Cnp protein, mouseEpidermal Growth FactorMyelin ProteinsProteoglycansWasf2 protein, mouseWiskott-Aldrich Syndrome Protein Familybrain repaircell migrationdemyelinationneural progenitor cellsSVZ

Identifiers

PMID25031401
PMCPMC4099541
OpenAlexW2071664956

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.