Evidence map›Paper›PMID 25031366›Full record

ArticleLearning & memory (Cold Spring Harbor, N.Y.)2014

Modulation of olfactory bulb network activity by serotonin: synchronous inhibition of mitral cells mediated by spatially localized GABAergic microcircuits.

Loren J Schmidt, Ben W Strowbridge

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Learning & memory (Cold Spring Harbor, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 31 citations in OpenAlex.

  1. Quantifying Peripheral Modulation of Olfaction by Trigeminal Agonists.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  2. Article
  3. Article
  4. Review
  5. Activation of Granule Cell Interneurons by Two Divergent Local Circuit Pathways in the Rat Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  6. Article
  7. Article
  8. Article
  9. Spatial Structure of Synchronized Inhibition in the Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017
    Article
  10. Article
  11. Review
  12. Article
  13. Cell-Type-Specific Modulation of Sensory Responses in Olfactory Bulb Circuits by Serotonergic Projections from the Raphe Nuclei.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016
    Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Loren J SchmidtDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.
Ben W StrowbridgeDepartment of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA bens@case.edu.
University School · US

Funding

LOCAL CIRCUITS IN THE OLFACTORY BULBR01DC004285 · NIDCD · CASE WESTERN RESERVE UNIVERSITY · PI Ben W Strowbridge · 2000 to 2026
$7.4M
Determining the cellular mechanisms of gamma oscillations in the olfactory bulb.F31DC011213 · NIDCD · CASE WESTERN RESERVE UNIVERSITY · PI SCHMIDT, LOREN JANES · 2011 to 2013
$114k
NIDCD NIH HHS F31 DC011213NIDCD NIH HHS F31-DC11213NIDCD NIH HHS R01 DC004285NIDCD NIH HHS R01-DC0428
6 · The paper itself

Abstract

Although inhibition has often been proposed as a central mechanism for coordinating activity in the olfactory system, relatively little is known about how activation of different inhibitory local circuit pathways can generate coincident inhibition of principal cells. We used serotonin (5-HT) as a pharmacological tool to induce spiking in ensembles of mitral cells (MCs), a primary output neuron in the olfactory bulb, and recorded intracellularly from pairs of MCs to directly assay coincident inhibitory input. We find that 5-HT disynaptically depolarized granule cells (GCs) only slightly but robustly increased the frequency of inhibitory postsynaptic inhibitory currents in MCs. Serotonin also triggered more coincident IPSCs in pairs of nearby MCs than expected by chance, including in MCs with truncated apical dendrites that lack glomerular synapses. That serotonin-triggered coincident inhibition in the absence of elevated GC somatic firing rates suggested that synchronized MC inhibition arose from glutamate receptor-mediated depolarization of GC dendrites or other (non-GC) interneurons outside the glomerular layer. Tetanic stimulation of GCL afferents to GCs triggered robust GC spiking, coincident inhibition in pairs of MCs, and recruited large-amplitude IPSCs in MCs. Enhancing neurotransmission through NMDARs by lowering the external Mg2+ concentration also increased inhibitory tone onto MCs but failed to promote synchronized inhibition. These results demonstrate that coincident MC inhibition can occur through multiple circuit pathways and suggests that the functional coordination between different GABAergic synapses in individual GCs can be dynamically regulated.

Indexed as

Action PotentialsAnimalsElectric Stimulationgamma-Aminobutyric AcidInhibitory Postsynaptic PotentialsMagnesiumMicrodissectionNeural InhibitionNeural PathwaysNeuronsOlfactory BulbPatch-Clamp TechniquesRats, Sprague-DawleyReceptors, GlutamateSerotoninTissue Culture Techniquesgamma-Aminobutyric AcidMagnesiumReceptors, GlutamateSerotonin

Identifiers

PMID25031366
PMCPMC4105717
OpenAlexW2097242782

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.