ArticleLearning & memory (Cold Spring Harbor, N.Y.)2014
Prefrontal consolidation supports the attainment of fear memory accuracy.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- β-catenin deficiency in forebrain excitatory neurons induces fear memory deficits and physiological alterations.Brain communications · 2026Article
- HAT p300/CBP Activity in the Prelimbic Cortex Underlies Reconsolidation of Contextual Fear Memory.Molecular neurobiology · 2025Article
- The Neuronal Hypofunction of Subdivisions of the Prefrontal Cortex Shows Differential Effects on Contingency Judgment Learning to Gauge Fear Responses.Neuroscience insights · 2024Article
- Expanding the canon: An inclusive neurobiology of thalamic and subthalamic fear circuits.Neuropharmacology · 2023Review
- Infralimbic cortex controls fear memory generalization and susceptibility to extinction during consolidation.Scientific reports · 2020Article
- Know safety, no fear.Neuroscience and biobehavioral reviews · 2020Review
- Elevated dopamine signaling from ventral tegmental area to prefrontal cortical parvalbumin neurons drives conditioned inhibition.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Chemogenetic stimulation of the infralimbic cortex reverses alcohol-induced fear memory overgeneralization.Scientific reports · 2019Article
- Differential fear conditioning generates prefrontal neural ensembles of safety signals.Behavioural brain research · 2019Article
- An Emergent Discriminative Learning Is Elicited During Multifrequency Testing.Frontiers in neuroscience · 2019Article
- Developmental changes in plasticity, synaptic, glia, and connectivity protein levels in rat medial prefrontal cortex.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Cued fear memory generalization increases over time.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- The Neurobiology of Fear Generalization.Frontiers in behavioral neuroscience · 2018Review
- Long-Lasting Effects of Prenatal Ethanol Exposure on Fear Learning and Development of the Amygdala.Frontiers in behavioral neuroscience · 2018Article
- Rubinstein-Taybi Syndrome and Epigenetic Alterations.Advances in experimental medicine and biology · 2017Review
- CBP-Dependent memory consolidation in the prefrontal cortex supports object-location learning.Hippocampus · 2015Article
- Prefrontal NMDA receptors expressed in excitatory neurons control fear discrimination and fear extinction.Neurobiology of learning and memory · 2015Article
- Prefrontal Cortex in Learning to Overcome Generalized Fear.Journal of experimental neuroscience · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The neural mechanisms underlying the attainment of fear memory accuracy for appropriate discriminative responses to aversive and nonaversive stimuli are unclear. Considerable evidence indicates that coactivator of transcription and histone acetyltransferase cAMP response element binding protein (CREB) binding protein (CBP) is critically required for normal neural function. CBP hypofunction leads to severe psychopathological symptoms in human and cognitive abnormalities in genetic mutant mice with severity dependent on the neural locus and developmental time of the gene inactivation. Here, we showed that an acute hypofunction of CBP in the medial prefrontal cortex (mPFC) results in a disruption of fear memory accuracy in mice. In addition, interruption of CREB function in the mPFC also leads to a deficit in auditory discrimination of fearful stimuli. While mice with deficient CBP/CREB signaling in the mPFC maintain normal responses to aversive stimuli, they exhibit abnormal responses to similar but nonrelevant stimuli when compared to control animals. These data indicate that improvement of fear memory accuracy involves mPFC-dependent suppression of fear responses to nonrelevant stimuli. Evidence from a context discriminatory task and a newly developed task that depends on the ability to distinguish discrete auditory cues indicated that CBP-dependent neural signaling within the mPFC circuitry is an important component of the mechanism for disambiguating the meaning of fear signals with two opposing values: aversive and nonaversive.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.